7YDS

The structure of the bispecific antibody targeted PD-L1 and 4-1BB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Programmed cell death 1 ligand 1	polymer	147	17080.7	1	UniProt (Q9NZQ7) Pfam (PF07686)	Homo sapiens (human)	PD-L1,PDCD1 ligand 1,Programmed death ligand 1,hPD-L1,B7 homolog 1,B7-H1
2	B (B)	Anti-PDL1-VH-CH1	polymer	221	23386.2	1		Homo sapiens (human)
3	C (C)	Anti-PDL1-VL-CL	polymer	217	23725.3	1		Homo sapiens (human)
4	D, E, F (A, B, C)	water	water		18.0	398	Chemie (HOH)

Sequence modifications

A: 1 - 136 (UniProt: Q9NZQ7)

PDB	External Database	Details
Gln 35	Asn 35	engineered mutation
Leu 137	-	expression tag
Glu 138	-	expression tag
Gly 139	-	expression tag
Gly 140	-	expression tag
Gly 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	64192.1
All*	Total formula weight	64192.1

*Water molecules are not included.