7YDS
The structure of the bispecific antibody targeted PD-L1 and 4-1BB
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Programmed cell death 1 ligand 1 | polymer | 147 | 17080.7 | 1 | UniProt (Q9NZQ7) Pfam (PF07686) In PDB | Homo sapiens (human) | PD-L1,PDCD1 ligand 1,Programmed death ligand 1,hPD-L1,B7 homolog 1,B7-H1 |
2 | B | Anti-PDL1-VH-CH1 | polymer | 221 | 23386.2 | 1 | Homo sapiens (human) | ||
3 | C | Anti-PDL1-VL-CL | polymer | 217 | 23725.3 | 1 | Homo sapiens (human) | ||
4 | water | water | 18.0 | 398 | Chemie (HOH) |
Sequence modifications
A: 1 - 136 (UniProt: Q9NZQ7)
PDB | External Database | Details |
---|---|---|
Gln 35 | Asn 35 | engineered mutation |
Leu 137 | - | expression tag |
Glu 138 | - | expression tag |
Gly 139 | - | expression tag |
Gly 140 | - | expression tag |
Gly 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
His 144 | - | expression tag |
His 145 | - | expression tag |
His 146 | - | expression tag |
His 147 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 64192.1 | |
All* | Total formula weight | 64192.1 |