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PDB: 1027 results

1Y7I
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Structural and biochemical studies identify tobacco SABP2 as a methylsalicylate esterase and further implicate it in plant innate immunity, Northeast Structural Genomics Target AR2241
Descriptor: 2-HYDROXYBENZOIC ACID, salicylic acid-binding protein 2
Authors:Forouhar, F, Yang, Y, Kumar, D, Chen, Y, Fridman, E, Park, S.W, Chiang, Y, Acton, T.B, Montelione, G.T, Pichersky, E, Klessig, D.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-08
Release date:2004-12-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
Proc.Natl.Acad.Sci.USA, 102, 2005
1Y7H
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Structural and biochemical studies identify tobacco SABP2 as a methylsalicylate esterase and further implicate it in plant innate immunity, Northeast Structural Genomics Target AR2241
Descriptor: THIOCYANATE ION, salicylic acid-binding protein 2
Authors:Forouhar, F, Yang, Y, Kumar, D, Chen, Y, Fridman, E, Park, S.W, Chiang, Y, Acton, T.B, Montelione, G.T, Pichersky, E, Klessig, D.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-08
Release date:2004-12-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
Proc.Natl.Acad.Sci.Usa, 102, 2005
2LJV
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Solution structure of Rhodostomin G50L mutant
Descriptor: Disintegrin rhodostomin
Authors:Chuang, W, Shiu, J, Chen, C, Chen, Y, Chang, Y, Huang, C.
Deposit date:2011-09-29
Release date:2012-10-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy
To be Published
8DCZ
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) M165Y Mutant in Complex with Nirmatrelvir
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-17
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8DFE
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant
Descriptor: 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-22
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8DGB
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Q192T Mutant in Complex with Inhibitor GC376
Descriptor: (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-23
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8DD1
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SARS-CoV-2 Main Protease (Mpro) H164N Mutant in Complex with Inhibitor GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-17
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8DD9
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant in Complex with Inhibitor GC376
Descriptor: (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-17
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
8DFN
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H164N Mutant
Descriptor: 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y.
Deposit date:2022-06-22
Release date:2022-07-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.
Acs Cent.Sci., 9, 2023
6LC1
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BU of 6lc1 by Molmil
Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter
Descriptor: DNA, DNA (25-MER), Nuclear receptor subfamily 4 group A member 1, ...
Authors:Jiang, L, Chen, Y.
Deposit date:2019-11-16
Release date:2019-12-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.
Biochem.Biophys.Res.Commun., 523, 2020
8DDI
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166N Mutant
Descriptor: 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Jacobs, L.M.C, Chen, Y.
Deposit date:2022-06-18
Release date:2022-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.
Plos Pathog., 19, 2023
8DDM
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Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166R Mutant in Complex with Inhibitor GC376
Descriptor: (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5
Authors:Lewandowski, E.M, Chen, Y.
Deposit date:2022-06-18
Release date:2022-08-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.
Plos Pathog., 19, 2023
7KX5
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Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A
Descriptor: 3C-like proteinase, GLYCEROL, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide
Authors:Sacco, M, Wang, J, Chen, Y.
Deposit date:2020-12-03
Release date:2020-12-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.
J.Am.Chem.Soc., 143, 2021
8HLM
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Crystal structure of p53/BCL2 fusion complex (complex 2)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Guo, M, Wang, H, Wei, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
8HLN
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Crystal structure of p53/BCL2 fusion complex(complex3)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Guo, M, Wei, H, Wang, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.354 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
8HLL
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Crystal structure of p53/BCL2 fusion complex (complex 1)
Descriptor: Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION
Authors:Wei, H, Guo, M, Wang, H, Chen, Y.
Deposit date:2022-11-30
Release date:2023-07-26
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity.
Nat Commun, 14, 2023
2O14
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BU of 2o14 by Molmil
X-Ray Crystal Structure of Protein YXIM_BACsu from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR595
Descriptor: Hypothetical protein yxiM, MANGANESE (II) ION, SULFATE ION
Authors:Kuzin, A.P, Chen, Y, Seetharaman, J, Chen, C.X, Fang, Y, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-11-28
Release date:2006-12-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray structure of the hypothetical protein YXIM_BACsu from Bacillus subtilis.
To be Published
1XKL
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Crystal Structure of Salicylic Acid-binding Protein 2 (SABP2) from Nicotiana tabacum, NESG Target AR2241
Descriptor: 2-AMINO-4H-1,3-BENZOXATHIIN-4-OL, salicylic acid-binding protein 2
Authors:Forouhar, F, Chen, Y, Chiang, Y, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-09-29
Release date:2004-11-30
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
Proc.Natl.Acad.Sci.USA, 102, 2005
6UN3
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with ticarcillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CALCIUM ION, GLYCEROL, ...
Authors:Sacco, M, Chen, Y.
Deposit date:2019-10-10
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase.
Antimicrob.Agents Chemother., 64, 2019
6UN1
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Crystal structure of Pseudomonas aeruginosa PBP3 in complex with temocillin
Descriptor: (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI
Authors:Sacco, M, Chen, Y.
Deposit date:2019-10-10
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase.
Antimicrob.Agents Chemother., 64, 2019
3GX8
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Structural and biochemical characterization of yeast monothiol glutaredoxin Grx5
Descriptor: Monothiol glutaredoxin-5, mitochondrial, SULFATE ION
Authors:Wang, Y, He, Y.X, Yu, J, Xiong, Y, Chen, Y, Zhou, C.Z.
Deposit date:2009-04-01
Release date:2010-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.673 Å)
Cite:Structural and biochemical characterization of yeast monothiol glutaredoxin Grx5
To be Published
7LYI
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Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-3
Descriptor: 3C-like proteinase, GLYCEROL, SODIUM ION, ...
Authors:Sacco, M, Wang, J, Chen, Y.
Deposit date:2021-03-07
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
7LYH
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Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-1
Descriptor: 3C-like proteinase, GLYCEROL, benzyl (1S,3aR,6aS)-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Authors:Sacco, M, Wang, J, Chen, Y.
Deposit date:2021-03-07
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
2G2X
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X-Ray Crystal Structure Protein Q88CH6 from Pseudomonas putida. Northeast Structural Genomics Consortium Target PpR72.
Descriptor: SULFATE ION, hypothetical protein PP5205
Authors:Kuzin, A.P, Chen, Y, Abashidze, M, Acton, T, Conover, K, Janjua, H, Ma, L.-C, Ho, C.K, Cunningham, K, Montelione, G, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-02-16
Release date:2006-03-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural genomics reveals EVE as a new ASCH/PUA-related domain.
Proteins, 75, 2009
2GBS
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BU of 2gbs by Molmil
NMR structure of Rpa0253 from Rhodopseudomonas palustris. Northeast structural genomics consortium target RpR3
Descriptor: Hypothetical protein Rpa0253
Authors:Ramelot, T.A, Cort, J.R, Conover, K, Chen, Y, Ma, L.C, Ciano, M, Xiao, R, Acton, T.B, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG)
Deposit date:2006-03-11
Release date:2006-04-11
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structural genomics reveals EVE as a new ASCH/PUA-related domain.
Proteins, 75, 2009

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