8W6N
 
 | | NaS1 with sulfate in IN/OUT state | | 分子名称: | SODIUM ION, SULFATE ION, Solute carrier family 13 member 1 | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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8W6O
 | | NaS1 in IN/IN state | | 分子名称: | CHOLESTEROL, SODIUM ION, Solute carrier family 13 member 1 | | 著者 | Chi, X, Chen, Y, Li, Y, Zhang, Y, Shen, Y, Chen, Y, Wang, Z, Yan, R. | | 登録日 | 2023-08-29 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism.
Sci Adv, 10, 2024
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5XP5
 | | C-Src in complex with ATP-Chf | | 分子名称: | MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid | | 著者 | Duan, Y, Guo, M, Dai, S, Chen, L, Chen, Y. | | 登録日 | 2017-06-01 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases.
J. Am. Chem. Soc., 139, 2017
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2QYK
 | | Crystal structure of PDE4A10 in complex with inhibitor NPV | | 分子名称: | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, Cyclic AMP-specific phosphodiesterase HSPDE4A10, MAGNESIUM ION, ... | | 著者 | Wang, H, Peng, M, Chen, Y, Geng, J, Robinson, H, Houslay, M. | | 登録日 | 2007-08-15 | | 公開日 | 2008-04-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
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3KVP
 | | Crystal Structure of Uncharacterized protein ymzC Precursor from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR378A | | 分子名称: | ACETIC ACID, Uncharacterized protein ymzC | | 著者 | Kuzin, A.P, Chen, Y, Seetharaman, J, Afonine, P, Fang, F, Xiao, R, Cunningham, K, Ma, L, Chen, C.X, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2009-11-30 | | 公開日 | 2010-02-02 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | | 主引用文献 | Northeast Structural Genomics Consortium Target SR378A
To be Published
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4NES
 | | Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP | | 分子名称: | UDP-N-acetylglucosamine 2-epimerase, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | 著者 | Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | | 登録日 | 2013-10-30 | | 公開日 | 2014-04-23 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc.
Proteins, 82, 2014
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3U4T
 | | Crystal Structure of the C-terminal part of the TPR repeat-containing protein Q11TI6_CYTH3 from Cytophaga hutchinsonii. Northeast Structural Genomics Consortium Target ChR11B. | | 分子名称: | TPR repeat-containing protein | | 著者 | Vorobiev, S, Neely, H, Chen, Y, Seetharaman, J, Patel, P, Xiao, R, Ciccosanti, C, Maglaqui, M, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2011-10-10 | | 公開日 | 2011-10-19 | | 実験手法 | X-RAY DIFFRACTION (2.282 Å) | | 主引用文献 | Crystal Structure of the C-terminal part of the TPR repeat-containing protein Q11TI6_CYTH3 from Cytophaga hutchinsonii.
To be Published
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6DFO
 | | Crystal structure of human GRP78 in complex with 8-bromoadenosine | | 分子名称: | 8-bromoadenosine, Endoplasmic reticulum chaperone BiP | | 著者 | Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. | | 登録日 | 2018-05-15 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Crystal structure of human GRP78 in complex with 8-bromoadenosine
To be Published
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6DO2
 | | Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine | | 分子名称: | 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP | | 著者 | Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. | | 登録日 | 2018-06-08 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
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6DFM
 | | Crystal structure of human GRP78 in complex with 8-aminoadenosine | | 分子名称: | (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP | | 著者 | Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. | | 登録日 | 2018-05-15 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
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4N4Y
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7YP2
 | | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement) | | 分子名称: | 6H2 heavy chain, 6H2 light chain, Envelope glycoprotein H | | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | | 登録日 | 2022-08-02 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Cell Rep Med, 4, 2023
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7YOY
 | | Cryo-EM structure of EBV gHgL-gp42 in complex with mAbs 3E8 and 5E3 (localized refinement) | | 分子名称: | 3E8 heavy chain, 3E8 light chain, 5E3 heavy chain, ... | | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | | 登録日 | 2022-08-02 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Cell Rep Med, 4, 2023
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7YP1
 | | Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 10E4 (localized refinement) | | 分子名称: | 10E4 heavy chain, 10E4 light chain, EBV gH, ... | | 著者 | Liu, L, Sun, H, Jiang, Y, Hong, J, Zheng, Q, Li, S, Chen, Y, Xia, N. | | 登録日 | 2022-08-02 | | 公開日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection.
Cell Rep Med, 4, 2023
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4Y1L
 | | Ubc9 Homodimer The Missing Link in Poly-SUMO Chain Formation | | 分子名称: | RWD domain-containing protein 3, SUMO-conjugating enzyme UBC9 | | 著者 | Aileen, Y.A, Ambaye, N.D, Li, Y.J, Vega, R, Bzymek, K, Williams, J.C, Hu, W, Chen, Y. | | 登録日 | 2015-02-08 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | RWD Domain as an E2 (Ubc9)-Interaction Module.
J.Biol.Chem., 290, 2015
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4XSQ
 | | Structure of a variable lymphocyte receptor-like protein Bf66946 from Branchiostoma floridae | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, variable lymphocyte receptor-like protein Bf66946 | | 著者 | Cao, D.D, Cheng, W, Jiang, Y.L, Wang, W.J, Li, Q, Chen, Y, Zhou, C.Z. | | 登録日 | 2015-01-22 | | 公開日 | 2016-03-23 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae.
Sci Rep, 6, 2016
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4X3Q
 | | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH | | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SibL | | 著者 | liu, J.S, Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | | 登録日 | 2014-12-01 | | 公開日 | 2015-11-25 | | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | | 主引用文献 | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH
To Be Published, 2015
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6XD7
 | | KPC-2 N170A mutant bound to hydrolyzed ampicillin at 1.65 A | | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | | 著者 | Pemberton, O.A, Chen, Y. | | 登録日 | 2020-06-10 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate.
J.Biol.Chem., 296, 2020
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6XD5
 | | Apo KPC-2 N170A mutant at 1.20 A | | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, SULFATE ION | | 著者 | Pemberton, O.A, Chen, Y. | | 登録日 | 2020-06-10 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate.
J.Biol.Chem., 296, 2020
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6XJ8
 | | KPC-2 N170A mutant bound to hydrolyzed imipenem at 2.05 A | | 分子名称: | (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC | | 著者 | Pemberton, O.A, Chen, Y. | | 登録日 | 2020-06-23 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate.
J.Biol.Chem., 296, 2020
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4V8X
 | | Structure of Thermus thermophilus ribosome | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | | 著者 | Feng, S, Chen, Y, Kamada, K, Wang, H, Tang, K, Wang, M, Gao, Y.G. | | 登録日 | 2013-07-19 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | Yoeb-Ribosome Structure: A Canonical Rnase that Requires the Ribosome for its Specific Activity.
Nucleic Acids Res., 41, 2013
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4N6F
 | | Crystal structure of Amycolatopsis orientalis BexX complexed with G6P | | 分子名称: | CALCIUM ION, FRUCTOSE -6-PHOSPHATE, Putative thiosugar synthase | | 著者 | Zhang, X, Zhang, Y, Kinsland, C, Sasaki, E, Sun, H.G, Lu, M.J, Liu, T, Ou, A, Li, J, Chen, Y, Liu, H, Ealick, S.E. | | 登録日 | 2013-10-11 | | 公開日 | 2014-05-14 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis.
Nature, 509, 2014
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8W9W
 | | The cryo-EM structure of human sphingomyelin synthase-related protein in complex with ceramide/phosphoethanolamine | | 分子名称: | PHOSPHORIC ACID MONO-(2-AMINO-ETHYL) ESTER, Sphingomyelin synthase-related protein 1, ~{N}-[(~{Z},2~{S},3~{R})-1,3-bis(oxidanyl)heptadec-4-en-2-yl]dodecanamide | | 著者 | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | | 登録日 | 2023-09-06 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | | 主引用文献 | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 2024
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8W9Y
 | | The cryo-EM structure of human sphingomyelin synthase-related protein | | 分子名称: | Sphingomyelin synthase-related protein 1 | | 著者 | Hu, K, Zhang, Q, Chen, Y, Yao, D, Zhou, L, Cao, Y. | | 登録日 | 2023-09-06 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis.
Nat.Struct.Mol.Biol., 2024
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4N6E
 | | Crystal structure of Amycolatopsis orientalis BexX/CysO complex | | 分子名称: | Putative thiosugar synthase, SULFATE ION, ThiS/MoaD family protein | | 著者 | Zhang, X, Zhang, Y, Kinsland, C, Sasaki, E, Sun, H.G, Lu, M.J, Liu, T, Ou, A, Li, J, Chen, Y, Liu, H, Ealick, S.E. | | 登録日 | 2013-10-11 | | 公開日 | 2014-05-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis.
Nature, 509, 2014
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