6XJ8

KPC-2 N170A mutant bound to hydrolyzed imipenem at 2.05 A

Summary for 6XJ8

Entry DOI	10.2210/pdb6xj8/pdb
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, (2R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-(2-methanimidamidoethylsulfanyl)-2,3-dihydro-1H-pyrrole -5-carboxylic acid (3 entities in total)
Functional Keywords	carbapenemase, beta-lactamase, hydrolase, antibiotic complex
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31418.58
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2020-06-23, release date: 2020-12-09, Last modification date: 2023-10-18)
Primary citation	Mehta, S.C.,Furey, I.M.,Pemberton, O.A.,Boragine, D.M.,Chen, Y.,Palzkill, T. KPC-2 beta-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J.Biol.Chem., 296:100155-100155, 2020 Cited by PubMed: 33273017 DOI: 10.1074/jbc.RA120.015050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation