6UN3
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![BU of 6un3 by Molmil](/molmil-images/mine/6un3) | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with ticarcillin | Descriptor: | (2R,4S)-2-[(1R)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CALCIUM ION, GLYCEROL, ... | Authors: | Sacco, M, Chen, Y. | Deposit date: | 2019-10-10 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
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6UN1
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![BU of 6un1 by Molmil](/molmil-images/mine/6un1) | Crystal structure of Pseudomonas aeruginosa PBP3 in complex with temocillin | Descriptor: | (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI | Authors: | Sacco, M, Chen, Y. | Deposit date: | 2019-10-10 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
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1P4E
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![BU of 1p4e by Molmil](/molmil-images/mine/1p4e) | Flpe W330F mutant-DNA Holliday Junction Complex | Descriptor: | 33-MER, 5'-D(*TP*AP*AP*GP*TP*TP*CP*CP*TP*AP*TP*TP*C)-3', 5'-D(*TP*TP*TP*AP*AP*AP*AP*GP*AP*AP*TP*AP*GP*GP*AP*AP*CP*TP*TP*C)-3', ... | Authors: | Rice, P.A, Chen, Y. | Deposit date: | 2003-04-23 | Release date: | 2003-05-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The role of the conserved Trp330 in Flp-mediated recombination. Functional and structural analysis J.Biol.Chem., 278, 2003
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6UNB
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![BU of 6unb by Molmil](/molmil-images/mine/6unb) | Crystal structure of CTX-M-14 in complex with temocillin | Descriptor: | (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Sacco, M, Chen, Y. | Deposit date: | 2019-10-11 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase. Antimicrob.Agents Chemother., 64, 2019
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6L19
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![BU of 6l19 by Molmil](/molmil-images/mine/6l19) | The crystal structure of competence or damage-inducible protein from Enterobacter asburiae | Descriptor: | CHLORIDE ION, GLYCEROL, PncC family amidohydrolase, ... | Authors: | Wang, L, Chen, Y, Liu, W, Lan, J, Shang, F, Xu, Y. | Deposit date: | 2019-09-28 | Release date: | 2019-10-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | The crystal structure of Competence or damage-inducible protein from Enterobacter asburiae To Be Published
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6L1K
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![BU of 6l1k by Molmil](/molmil-images/mine/6l1k) | Crystal structure of NADH-dependent butanol dehydrogenase A from Fusobacterium nucleatum | Descriptor: | NADH-dependent butanol dehydrogenase A, PHOSPHATE ION | Authors: | Lan, J, Shang, F, Liu, W, Xu, Y, Chen, Y. | Deposit date: | 2019-09-29 | Release date: | 2019-10-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal structure of NADH-dependent butanol dehydrogenase A from Fusobacterium nucleatum To Be Published
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1IAY
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![BU of 1iay by Molmil](/molmil-images/mine/1iay) | CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG | Descriptor: | 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, 2-AMINO-4-(2-AMINO-ETHOXY)-BUTYRIC ACID, PYRIDOXAL-5'-PHOSPHATE | Authors: | Huai, Q, Xia, Y, Chen, Y, Callahan, B, Li, N, Ke, H. | Deposit date: | 2001-03-24 | Release date: | 2001-04-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms J.Biol.Chem., 276, 2001
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6M22
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![BU of 6m22 by Molmil](/molmil-images/mine/6m22) | KCC3 bound with DIOA | Descriptor: | 2-[[(2~{R})-2-butyl-6,7-bis(chloranyl)-2-cyclopentyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Chi, X.M, Li, X.R, Chen, Y, Zhang, Y.Y, Su, Q, Zhou, Q. | Deposit date: | 2020-02-26 | Release date: | 2020-11-04 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Res., 31, 2021
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1IAX
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![BU of 1iax by Molmil](/molmil-images/mine/1iax) | CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP | Descriptor: | 1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | Authors: | Huai, Q, Xia, Y, Chen, Y, Callahan, B, Li, N, Ke, H. | Deposit date: | 2001-03-24 | Release date: | 2001-04-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms J.Biol.Chem., 276, 2001
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3QRF
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![BU of 3qrf by Molmil](/molmil-images/mine/3qrf) | Structure of a domain-swapped FOXP3 dimer | Descriptor: | Forkhead box protein P3, MAGNESIUM ION, Nuclear factor of activated T-cells, ... | Authors: | Bandukwala, H.S, Wu, Y, Feurer, M, Chen, Y, Barbosa, B, Ghosh, S, Stroud, J.C, Benoist, C, Mathis, D, Rao, A, Chen, L. | Deposit date: | 2011-02-17 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells. Immunity, 34, 2011
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3V3E
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![BU of 3v3e by Molmil](/molmil-images/mine/3v3e) | Crystal Structure of the Human Nur77 Ligand-binding Domain | Descriptor: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | Authors: | Zhang, Q, Shi, C, Yang, K, Chen, Y, Zhan, Y, Wu, Q, Lin, T. | Deposit date: | 2011-12-13 | Release date: | 2012-09-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK Nat.Chem.Biol., 8, 2012
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3V3Q
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![BU of 3v3q by Molmil](/molmil-images/mine/3v3q) | Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with Ethyl 2-[2,3,4 trimethoxy-6(1-octanoyl)phenyl]acetate | Descriptor: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1, SODIUM ION, ... | Authors: | Zhang, Q, Shi, C, Yang, K, Chen, Y, Zhan, Y, Wu, Q, Lin, T. | Deposit date: | 2011-12-14 | Release date: | 2012-09-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK Nat.Chem.Biol., 8, 2012
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4Q48
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![BU of 4q48 by Molmil](/molmil-images/mine/4q48) | |
7DNJ
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![BU of 7dnj by Molmil](/molmil-images/mine/7dnj) | K63-polyUb MDA5CARDs complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7DNI
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![BU of 7dni by Molmil](/molmil-images/mine/7dni) | MDA5 CARDs-MAVS CARD polyUb complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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4IXA
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![BU of 4ixa by Molmil](/molmil-images/mine/4ixa) | Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis | Descriptor: | Response regulator SaeR | Authors: | Chen, Y.R, Chen, S.C, Yang, C.S, Kuan, S.M, Liu, Y.H, Chen, Y. | Deposit date: | 2013-01-24 | Release date: | 2014-01-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of DNA-binding domain of the response regulator SaeR from Staphylococcus epidermidis To be Published
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4JIS
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![BU of 4jis by Molmil](/molmil-images/mine/4jis) | Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis | Descriptor: | ribitol-5-phosphate cytidylyltransferase | Authors: | Yang, C.S, Chen, S.C, Chen, Y.R, Kuan, S.M, Liu, Y.H, Chen, Y. | Deposit date: | 2013-03-06 | Release date: | 2014-03-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.772 Å) | Cite: | Crystal structure of ribitol 5-phosphate cytidylyltransferase (TarI) from Bacillus subtilis To be Published
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4QVG
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![BU of 4qvg by Molmil](/molmil-images/mine/4qvg) | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in its apo form | Descriptor: | SibL | Authors: | Liu, J.S, Chen, S.C, Huang, C.H, Yang, C.S, Chen, Y. | Deposit date: | 2014-07-15 | Release date: | 2015-05-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and mechanism of an antibiotics-synthesizing 3-hydroxykynurenine C-methyltransferase Sci Rep, 5, 2015
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4U1Q
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![BU of 4u1q by Molmil](/molmil-images/mine/4u1q) | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with 3HK and SAH | Descriptor: | (2S)-2-amino-4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid, S-ADENOSYL-L-HOMOCYSTEINE, SibL | Authors: | liu, J.S, Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | Deposit date: | 2014-07-16 | Release date: | 2015-08-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.085 Å) | Cite: | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with 3HK and SAH To Be Published
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4U88
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![BU of 4u88 by Molmil](/molmil-images/mine/4u88) | |
4KYH
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![BU of 4kyh by Molmil](/molmil-images/mine/4kyh) | Crystal structure of mouse glyoxalase I complexed with zopolrestat | Descriptor: | 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, Lactoylglutathione lyase, ZINC ION | Authors: | Zhai, J, Yuan, M, Zhang, L, Chen, Y, Zhang, H, Chen, S, Zhao, Y. | Deposit date: | 2013-05-29 | Release date: | 2013-08-07 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Zopolrestat as a human glyoxalase I inhibitor and its structural basis. Chemmedchem, 8, 2013
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7TOB
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![BU of 7tob by Molmil](/molmil-images/mine/7tob) | Crystal structure of the SARS-CoV-2 Omicron main protease (Mpro) in complex with inhibitor GC376 | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER | Authors: | Sacco, M.D, Wang, J, Chen, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-02-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition. Cell Res., 32, 2022
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3BVD
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![BU of 3bvd by Molmil](/molmil-images/mine/3bvd) | Structure of Surface-engineered Cytochrome ba3 Oxidase from Thermus thermophilus under Xenon Pressure, 100psi 5min | Descriptor: | COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, Cytochrome c oxidase subunit 1, ... | Authors: | Luna, V.M, Chen, Y, Fee, J.A, Stout, C.D. | Deposit date: | 2008-01-07 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Crystallographic Studies of Xe and Kr Binding within the Large Internal Cavity of Cytochrome ba3 from Thermus thermophilus: Structural Analysis and Role of Oxygen Transport Channels in the Heme-Cu Oxidases. Biochemistry, 47, 2008
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4KYK
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![BU of 4kyk by Molmil](/molmil-images/mine/4kyk) | Crystal structure of mouse glyoxalase I complexed with indomethacin | Descriptor: | INDOMETHACIN, Lactoylglutathione lyase, ZINC ION | Authors: | Zhai, J, Yuan, M, Zhang, L, Chen, Y, Zhang, H, Chen, S, Zhao, Y. | Deposit date: | 2013-05-29 | Release date: | 2013-08-07 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Zopolrestat as a human glyoxalase I inhibitor and its structural basis. Chemmedchem, 8, 2013
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3QJT
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![BU of 3qjt by Molmil](/molmil-images/mine/3qjt) | The structure of and photolytic induced changes of carbon monoxide binding to the cytochrome ba3-oxidase from Thermus thermophilus | Descriptor: | CARBON MONOXIDE, COPPER (I) ION, Cytochrome c oxidase polypeptide 2A, ... | Authors: | Liu, B, Zhang, Y, Sage, J.T, Doukov, T, Chen, Y, Stout, C.D, Fee, J.A. | Deposit date: | 2011-01-30 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural changes that occur upon photolysis of the Fe(II)(a3)-CO complex in the cytochrome ba(3)-oxidase of Thermus thermophilus: A combined X-ray crystallographic and infrared spectral study demonstrates CO binding to Cu(B). Biochim.Biophys.Acta, 1817, 2012
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