3QRF

Structure of a domain-swapped FOXP3 dimer

Summary for 3QRF

Related1a02 1owr 2as5 2a07
DescriptorNuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, human hARRE2 DNA (Plus Strand), ... (6 entities in total)
Functional Keywordsbeta barrel, domain swap, forkhead domain, immnoglobulin fold, protein-dna complex, double helix, transcription regulation, dna binding, nucleus, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm Q13469
Nucleus  Q9BZS1
Total number of polymer chains10
Total molecular weight130608.36
Authors
Bandukwala, H.S.,Wu, Y.,Feurer, M.,Chen, Y.,Barbosa, B.,Ghosh, S.,Stroud, J.C.,Benoist, C.,Mathis, D.,Rao, A.,Chen, L. (deposition date: 2011-02-17, release date: 2011-04-20, Last modification date: 2018-01-24)
Primary citation
Bandukwala, H.S.,Wu, Y.,Feuerer, M.,Chen, Y.,Barboza, B.,Ghosh, S.,Stroud, J.C.,Benoist, C.,Mathis, D.,Rao, A.,Chen, L.
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34:479-491, 2011
PubMed: 21458306 (PDB entries with the same primary citation)
DOI: 10.1016/j.immuni.2011.02.017
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278326.8%6.8%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3qrf
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Molmil generated image of 3qrf
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Molmil generated image of 3qrf
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More Biological unit images

Molmil generated image of 3qrf
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Molmil generated image of 3qrf
rotated about x axis by 90°
Molmil generated image of 3qrf
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3qrf.pdb2.gz [93.76 KB])
Coordinate files for Biological unit (3qrf.pdb1.gz [93.94 KB])