Structure of a domain-swapped FOXP3 dimer

Summary for 3QRF

Related1a02 1owr 2as5 2a07
DescriptorNuclear factor of activated T-cells, cytoplasmic 2, Forkhead box protein P3, human hARRE2 DNA (Plus Strand), ... (6 entities in total)
Functional Keywordsbeta barrel, domain swap, forkhead domain, immnoglobulin fold, protein-dna complex, double helix, transcription regulation, dna binding, nucleus, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm Q13469
Nucleus  Q9BZS1
Total number of polymer chains10
Total molecular weight130608.36
Bandukwala, H.S.,Wu, Y.,Feurer, M.,Chen, Y.,Barbosa, B.,Ghosh, S.,Stroud, J.C.,Benoist, C.,Mathis, D.,Rao, A.,Chen, L. (deposition date: 2011-02-17, release date: 2011-04-20, Last modification date: 2018-01-24)
Primary citation
Bandukwala, H.S.,Wu, Y.,Feuerer, M.,Chen, Y.,Barboza, B.,Ghosh, S.,Stroud, J.C.,Benoist, C.,Mathis, D.,Rao, A.,Chen, L.
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells.
Immunity, 34:479-491, 2011
PubMed: 21458306 (PDB entries with the same primary citation)
DOI: 10.1016/j.immuni.2011.02.017
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27832 6.8% 6.8% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02