3QRF
Structure of a domain-swapped FOXP3 dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
| G | 0003700 | molecular_function | DNA-binding transcription factor activity |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0043565 | molecular_function | sequence-specific DNA binding |
| H | 0003700 | molecular_function | DNA-binding transcription factor activity |
| H | 0006355 | biological_process | regulation of DNA-templated transcription |
| H | 0043565 | molecular_function | sequence-specific DNA binding |
| I | 0003700 | molecular_function | DNA-binding transcription factor activity |
| I | 0006355 | biological_process | regulation of DNA-templated transcription |
| I | 0043565 | molecular_function | sequence-specific DNA binding |
| M | 0003677 | molecular_function | DNA binding |
| M | 0003700 | molecular_function | DNA-binding transcription factor activity |
| M | 0006355 | biological_process | regulation of DNA-templated transcription |
| N | 0003677 | molecular_function | DNA binding |
| N | 0003700 | molecular_function | DNA-binding transcription factor activity |
| N | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG F 1 |
| Chain | Residue |
| F | LEU389 |
| F | SER390 |
| F | HIS392 |
| F | PHE395 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG G 1 |
| Chain | Residue |
| G | LEU389 |
| G | SER390 |
| G | HIS392 |
| G | PHE395 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG H 1 |
| Chain | Residue |
| H | SER390 |
| H | HIS392 |
| H | PHE395 |
| H | LEU389 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG I 1 |
| Chain | Residue |
| I | LEU389 |
| I | SER390 |
| I | HIS392 |
| I | PHE395 |
Functional Information from PROSITE/UniProt
| site_id | PS00658 |
| Number of Residues | 7 |
| Details | FORK_HEAD_2 Fork head domain signature 2. WKNAIRH |
| Chain | Residue | Details |
| F | TRP381-HIS387 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by PCSK1 or PCSK2 => ECO:0000269|PubMed:19117830 |
| Chain | Residue | Details |
| F | ARG417 | |
| G | ARG417 | |
| H | ARG417 | |
| I | ARG417 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q99JB6 |
| Chain | Residue | Details |
| F | LYS393 | |
| G | LYS393 | |
| H | LYS393 | |
| I | LYS393 |
