6JPF
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6JB3
| Structure of SUR1 subunit bound with repaglinide | Descriptor: | ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide | Authors: | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | Deposit date: | 2019-01-25 | Release date: | 2019-05-22 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019
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6JT2
| Structure of human soluble guanylate cyclase in the NO activated state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-09-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT0
| Structure of human soluble guanylate cyclase in the unliganded state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT1
| Structure of human soluble guanylate cyclase in the heme oxidised state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6L65
| Sirtuin 2 protein with H3K18 myristoylated peptide | Descriptor: | MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ... | Authors: | Chen, L.F. | Deposit date: | 2019-10-28 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
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6L66
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6L72
| Sirtuin 2 demyristoylation native final product | Descriptor: | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate | Authors: | Chen, L.F. | Deposit date: | 2019-10-30 | Release date: | 2021-03-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide To Be Published
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6L71
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7D9R
| Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9U
| Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9S
| Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9T
| Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7VLB
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7VVH
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7VVD
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7VUO
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2HJM
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7E16
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1D8F
| CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR. | Descriptor: | CALCIUM ION, N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYL-PIPERAZINE-2-CARBOXAMIDE, STROMELYSIN-1 PRECURSOR, ... | Authors: | Cheng, M.Y, De, B, Pikul, S, Almstead, N.G, Natchus, M.G, Anastasio, M.V, McPhail, S.J, Snider, C.E, Taiwo, Y.O, Chen, L.Y. | Deposit date: | 1999-10-22 | Release date: | 2000-10-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J.Med.Chem., 43, 2000
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1DK4
| CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE | Descriptor: | INOSITOL MONOPHOSPHATASE, PHOSPHATE ION, ZINC ION | Authors: | Stec, B, Yang, H, Johnson, K.A, Chen, L, Roberts, M.F. | Deposit date: | 1999-12-06 | Release date: | 2000-11-08 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase. Nat.Struct.Biol., 7, 2000
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4WK8
| FOXP3 forms a domain-swapped dimer to bridge DNA | Descriptor: | DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3 | Authors: | Chen, Y, Chen, L. | Deposit date: | 2014-10-01 | Release date: | 2015-01-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.4006 Å) | Cite: | DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res., 43, 2015
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5JKG
| The crystal structure of FGFR4 kinase domain in complex with LY2874455 | Descriptor: | 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol, Fibroblast growth factor receptor 4 | Authors: | Wu, D, Chen, L, Chen, Y. | Deposit date: | 2016-04-26 | Release date: | 2016-10-05 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.352 Å) | Cite: | Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 Plos One, 11, 2016
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4WUY
| Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor | Descriptor: | 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ... | Authors: | Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M. | Deposit date: | 2014-11-04 | Release date: | 2015-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J.Biol.Chem., 290, 2015
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7YEG
| SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | Authors: | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | Deposit date: | 2022-07-05 | Release date: | 2022-08-24 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol, 7, 2022
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