7ECA

Crystal structure of the Keap1 complex with a peptide base on ETGE motif.

Summary for 7ECA

• Entry DOI: 10.2210/pdb7eca/pdb
• Descriptor: Kelch-like ECH-associated protein 1, LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-LEU-PRO, SULFATE ION, ... (4 entities in total)
• Functional Keywords: nrf2, oxidative stress, cancer, cytosolic protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 40821.12

Authors

Cheng, L.,Wang, C. (deposition date: 2021-03-11, release date: 2022-03-16, Last modification date: 2023-11-29)

• Primary citation: Cheng, L.,Wang, H.,Li, S.,Liu, Z.,Wang, C.; New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.; Life Sci, 282:119791-119791, 2021; PubMed: 34229009; DOI: 10.1016/j.lfs.2021.119791

Experimental method

X-RAY DIFFRACTION (2.00006351943 Å)