7ECA
Crystal structure of the Keap1 complex with a peptide base on ETGE motif.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 701 |
| Chain | Residue |
| A | CYS434 |
| A | ILE435 |
| A | HIS436 |
| A | ARG459 |
| A | ARG494 |
| A | ARG498 |
| A | HOH803 |
| A | HOH812 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 702 |
| Chain | Residue |
| A | HIS437 |
| A | SER438 |
| A | SER439 |
| A | ARG494 |
| A | HOH810 |
| A | HOH811 |
| A | HOH813 |
| A | HOH833 |
| A | HOH897 |
| A | ILE435 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 703 |
| Chain | Residue |
| A | HIS451 |
| A | LEU452 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 704 |
| Chain | Residue |
| A | ALA407 |
| A | SER408 |
| A | HOH816 |
| A | HOH827 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 705 |
| Chain | Residue |
| A | ARG415 |
| A | GLY462 |
| A | GLY509 |
| A | ALA556 |
| A | HOH817 |
| A | HOH818 |
| A | HOH829 |
| A | HOH842 |
| A | HOH871 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 706 |
| Chain | Residue |
| A | HIS424 |
| A | GLU444 |
| A | PRO445 |
| A | GLU446 |
| A | ARG447 |
| A | HOH837 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 707 |
| Chain | Residue |
| A | VAL463 |
| A | GLY464 |
| A | VAL465 |
| A | ALA510 |
| A | VAL512 |
| A | ILE559 |
| A | HOH871 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 708 |
| Chain | Residue |
| A | ILE421 |
| A | ASP422 |
| A | HIS424 |
| A | TYR426 |
| A | ARG442 |
| A | PRO492 |
| A | HOH802 |
| A | HOH835 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 709 |
| Chain | Residue |
| A | THR481 |
| A | ASN482 |
| A | ARG483 |
| A | GLY527 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 710 |
| Chain | Residue |
| A | VAL370 |
| A | GLY371 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 711 |
| Chain | Residue |
| A | ARG442 |
| A | GLU444 |
| A | ARG447 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"Kelch 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"Kelch 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"22014577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Motif: {"description":"ETGE motif","evidences":[{"source":"PubMed","id":"15282312","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16581765","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16790436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
