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PDB: 616 件
6JPF
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BU of 6jpf by Molmil
Structure of atOSCA1.1 channel at 3.52A
分子名称: Protein OSCA1
著者Chen, L, Zhang, M, Kang, Y, Wu, J.X.
登録日2019-03-26
公開日2019-04-10
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献Structure of the mechanosensitive OSCA channels.
Nat. Struct. Mol. Biol., 25, 2018
6JB3
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BU of 6jb3 by Molmil
Structure of SUR1 subunit bound with repaglinide
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide
著者Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y.
登録日2019-01-25
公開日2019-05-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
6JT2
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BU of 6jt2 by Molmil
Structure of human soluble guanylate cyclase in the NO activated state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-09-04
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6JT0
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BU of 6jt0 by Molmil
Structure of human soluble guanylate cyclase in the unliganded state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6JT1
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BU of 6jt1 by Molmil
Structure of human soluble guanylate cyclase in the heme oxidised state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE
著者Chen, L, Kang, Y, Liu, R, Wu, J.-X.
登録日2019-04-08
公開日2019-08-28
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
6L65
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BU of 6l65 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide
分子名称: MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ...
著者Chen, L.F.
登録日2019-10-28
公開日2020-11-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L66
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BU of 6l66 by Molmil
Sirtuin 2 protein with H3K18 myristoylated peptide and intact NAD molecule
分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
著者Chen, L.F.
登録日2019-10-28
公開日2020-11-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.169 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L72
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Sirtuin 2 demyristoylation native final product
分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
6L71
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Sirtuin 2 demyristoylation native intermediate I & II mixture
分子名称: NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE, PRO-ARG-LYS-GLN-LEU-ALA, ...
著者Chen, L.F.
登録日2019-10-30
公開日2021-03-31
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.109 Å)
主引用文献Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
7D9R
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BU of 7d9r by Molmil
Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9U
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BU of 7d9u by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound activated state
分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9S
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BU of 7d9s by Molmil
Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state
分子名称: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ...
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7D9T
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BU of 7d9t by Molmil
Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state
分子名称: 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1
著者Chen, L, Liu, R, Kang, Y.
登録日2020-10-14
公開日2021-08-11
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
7VLB
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BU of 7vlb by Molmil
Crystal structure of UGT109A1 from Bacillus
分子名称: UDP-glycosyltransferase, URIDINE-5'-DIPHOSPHATE
著者Chen, L.Q, Zhang, Y.
登録日2021-10-02
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of UGT109A1 from Bacillus
To Be Published
7VVH
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BU of 7vvh by Molmil
Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation E140G
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1,Potassium voltage-gated channel subfamily KQT member 1
著者Chen, L.
登録日2021-11-06
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.296 Å)
主引用文献Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L
To Be Published
7VVD
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BU of 7vvd by Molmil
Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation Q135P
分子名称: CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1,Potassium voltage-gated channel subfamily KQT member 1
著者Chen, L.
登録日2021-11-05
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.134 Å)
主引用文献Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L
To Be Published
7VUO
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BU of 7vuo by Molmil
Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L
分子名称: CALCIUM ION, Calmodulin-1, Kv7.1
著者Chen, L.
登録日2021-11-03
公開日2022-11-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.679 Å)
主引用文献Crystal Structure of the Kv7.1 C-terminal Domain in Complex with Calmodulin disease mutation F141L
To Be Published
2HJM
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BU of 2hjm by Molmil
Crystal structure of a singleton protein PF1176 from P. furiosus
分子名称: Hypothetical protein PF1176
著者Chen, L.Q, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
登録日2006-06-30
公開日2007-07-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a singleton protein PF1176 from P. furiosus
To be Published
7E16
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BU of 7e16 by Molmil
crystal structure of GDSL esterase from Geobacillus thermodenitrificans
分子名称: GDSL-family esterase
著者Chen, L.
登録日2021-01-31
公開日2021-04-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Rational engineering of substrate selectivity of GDSL esterase from Geobacillus thermodenitrificans
To Be Published
1D8F
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BU of 1d8f by Molmil
CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A PIPERAZINE BASED INHIBITOR.
分子名称: CALCIUM ION, N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYL-PIPERAZINE-2-CARBOXAMIDE, STROMELYSIN-1 PRECURSOR, ...
著者Cheng, M.Y, De, B, Pikul, S, Almstead, N.G, Natchus, M.G, Anastasio, M.V, McPhail, S.J, Snider, C.E, Taiwo, Y.O, Chen, L.Y.
登録日1999-10-22
公開日2000-10-23
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Design and synthesis of piperazine-based matrix metalloproteinase inhibitors.
J.Med.Chem., 43, 2000
1DK4
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BU of 1dk4 by Molmil
CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE
分子名称: INOSITOL MONOPHOSPHATASE, PHOSPHATE ION, ZINC ION
著者Stec, B, Yang, H, Johnson, K.A, Chen, L, Roberts, M.F.
登録日1999-12-06
公開日2000-11-08
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献MJ0109 is an enzyme that is both an inositol monophosphatase and the 'missing' archaeal fructose-1,6-bisphosphatase.
Nat.Struct.Biol., 7, 2000
4WK8
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BU of 4wk8 by Molmil
FOXP3 forms a domain-swapped dimer to bridge DNA
分子名称: DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), Forkhead box protein P3
著者Chen, Y, Chen, L.
登録日2014-10-01
公開日2015-01-21
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.4006 Å)
主引用文献DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
5JKG
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BU of 5jkg by Molmil
The crystal structure of FGFR4 kinase domain in complex with LY2874455
分子名称: 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol, Fibroblast growth factor receptor 4
著者Wu, D, Chen, L, Chen, Y.
登録日2016-04-26
公開日2016-10-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Plos One, 11, 2016
4WUY
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BU of 4wuy by Molmil
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
分子名称: 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, GLYCEROL, N-lysine methyltransferase SMYD2, ...
著者Nguyen, H, Allali-Hassani, A, Antonysamy, S, Chang, S, Chen, L.H, Curtis, C, Emtage, S, Fan, L, Gheyi, T, Li, F, Liu, S, Martin, J.R, Mendel, D, Olsen, J.B, Pelletier, L, Shatseva, T, Wu, S, Zhang, F.F, Arrowsmith, C.H, Brown, P.J, Campbell, R.M, Garcia, B.A, Barsyte-Lovejoy, D, Mader, M, Vedadi, M.
登録日2014-11-04
公開日2015-04-08
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
J.Biol.Chem., 290, 2015
7YEG
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BU of 7yeg by Molmil
SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs and 3 ACE2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ...
著者Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X.
登録日2022-07-05
公開日2022-08-24
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
Nat Microbiol, 7, 2022

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