8HB2
 
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8HAZ
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8HBB
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8OIO
 | | Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Kelch-like protein 12, ... | | Authors: | Dalietou, E.V, Chen, Z, Ramdass, A.E, Manning, C, Richardson, W, Aitmakhanova, K, Platt, M, Pike, A.C.W, Fedorov, O, Brennan, P, Bullock, A.N. | | Deposit date: | 2023-03-23 | | Release date: | 2024-04-03 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.954 Å) | | Cite: | Crystal structure of the kelch domain of human KLHL12 in complex with PLEKHA4 peptide
To Be Published
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8SNX
 | | Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter | | Descriptor: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L | | Authors: | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | | Deposit date: | 2023-04-28 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
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8SNY
 | | Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter | | Descriptor: | Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L | | Authors: | Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. | | Deposit date: | 2023-04-28 | | Release date: | 2023-12-20 | | Last modified: | 2024-01-31 | | Method: | ELECTRON MICROSCOPY (3.41 Å) | | Cite: | Structures of the promoter-bound respiratory syncytial virus polymerase.
Nature, 625, 2024
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2JYV
 | | Human Granulin F | | Descriptor: | Granulin-2 | | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | | Deposit date: | 2007-12-19 | | Release date: | 2008-04-22 | | Last modified: | 2024-10-09 | | Method: | SOLUTION NMR | | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities.
Protein Sci., 17, 2008
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2JYE
 | | Human Granulin A | | Descriptor: | Granulin A | | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | | Deposit date: | 2007-12-13 | | Release date: | 2008-04-22 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities.
Protein Sci., 17, 2008
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8STL
 | | Crystal Structure of Nanobody PIK3_Nb16 against wild-type PI3Kalpha | | Descriptor: | Nanobody PIK3_Nb16, SULFATE ION | | Authors: | Nwafor, J.N, Srinivasan, L, Chen, Z, Gabelli, S.B, Iheanacho, A, Alzogaray, V, Klinke, S. | | Deposit date: | 2023-05-10 | | Release date: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Development of isoform specific nanobodies for Class I PI3Ks
To be published
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1T31
 | | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E, Pereira, P.J.B, Wang, Z.M, Rubin, H, Huber, R, Bode, W, Schechter, N.M, Strobl, S. | | Deposit date: | 2004-04-23 | | Release date: | 2005-03-01 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
J.Biol.Chem., 280, 2005
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3OMD
 | | Crystal structure of unknown function protein from Leptospirillum rubarum | | Descriptor: | Uncharacterized protein | | Authors: | Chang, C, Xu, X, Cui, H, Chen, Z, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2010-08-26 | | Release date: | 2010-09-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of unknown function protein from Leptospirillum rubarum
To be Published
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2JYT
 | | Human Granulin C, isomer 1 | | Descriptor: | Granulin-5 | | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | | Deposit date: | 2007-12-19 | | Release date: | 2008-04-22 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities.
Protein Sci., 17, 2008
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7QZQ
 | | Crystal structure of the kelch domain of human KBTBD12 | | Descriptor: | 1,2-ETHANEDIOL, Kelch repeat and BTB domain-containing protein 12, SODIUM ION | | Authors: | Manning, C.E, Chen, Z, Chen, X, Bradshaw, W.J, Bakshi, S, Mckinley, G, Chalk, R, Burgess-Brown, N, von Delft, F, Bullock, A.N. | | Deposit date: | 2022-01-31 | | Release date: | 2022-05-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structure of the kelch domain of human KBTBD12
To Be Published
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8GQ6
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1 dimeric complex | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | Authors: | Sun, L, Chen, Z, Hu, Y, Mao, Q. | | Deposit date: | 2022-08-29 | | Release date: | 2023-09-06 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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6VLS
 | | Structure of C-terminal fragment of Vip3A toxin | | Descriptor: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein,Vip3Aa | | Authors: | Jiang, K, Zhang, Y, Chen, Z, Gao, X. | | Deposit date: | 2020-01-25 | | Release date: | 2020-07-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin ofBacillus thuringiensis.
Toxins, 12, 2020
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8H3A
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-08 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.51 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H36
 | | Cryo-EM Structure of the KBTBD2-CUL3-Rbx1-p85a dimeric complex | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-08 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H33
 | | Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-07 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (7.86 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3Q
 | | Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | | Descriptor: | Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-09 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H3R
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8 dimeric complex | | Descriptor: | Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch repeat and BTB domain-containing protein 2, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-09 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (6.36 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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8H38
 | | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | | Descriptor: | COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-08 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4.25 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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1BXA
 | | AMICYANIN REDUCED, PH 4.4, 1.3 ANGSTROMS | | Descriptor: | COPPER (I) ION, PROTEIN (AMICYANIN) | | Authors: | Cunane, L.M, Chen, Z.W, Durley, R.C.E, Mathews, F.S. | | Deposit date: | 1998-10-01 | | Release date: | 1998-10-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Molecular basis for interprotein complex-dependent effects on the redox properties of amicyanin.
Biochemistry, 37, 1998
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8HM3
 | | Complex of PPIase-BfUbb | | Descriptor: | GLYCEROL, MAGNESIUM ION, Peptidylprolyl isomerase, ... | | Authors: | Xu, J.H, Chen, Z, Gao, X. | | Deposit date: | 2022-12-02 | | Release date: | 2023-11-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Bacteroides fragilis ubiquitin homologue drives intraspecies bacterial competition in the gut microbiome.
Nat Microbiol, 9, 2024
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8XQ3
 | | Structure of Nipah virus Bangladesh string G protein ectodomain tetramer bound to single-domain antibody n425 at 5.87 Angstroms overall resolution | | Descriptor: | Nipah virus Bangladesh string G protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Sun, L, Chen, Z, Sun, Y, Mao, Q. | | Deposit date: | 2024-01-04 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (5.87 Å) | | Cite: | Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein.
Nat Commun, 15, 2024
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8XPS
 | | Structure of Nipah virus Bangladesh string G protein ectodomain monomer bound to single-domain antibody n425 at 3.22 Angstroms overall resolution | | Descriptor: | Nipah virus Bangladesh string G protein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Sun, L, Chen, Z, Sun, Y, Mao, Q. | | Deposit date: | 2024-01-04 | | Release date: | 2024-09-18 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein.
Nat Commun, 15, 2024
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