1T31

A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation

Summary for 1T31

Entry DOI	10.2210/pdb1t31/pdb
Related	1PJP
Descriptor	Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	human chymase, serine proteinase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	27234.77
Authors	de Garavilla, L.,Greco, M.N.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Abraham, W.M.,Sukumar, N.,Chen, Z.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Andrade-Gordon, P.,Damiano, B.P.,Maryanoff, B.E.,Pereira, P.J.B.,Wang, Z.M.,Rubin, H.,Huber, R.,Bode, W.,Schechter, N.M.,Strobl, S. (deposition date: 2004-04-23, release date: 2005-03-01, Last modification date: 2023-08-23)
Primary citation	de Garavilla, L.,Greco, M.N.,Sukumar, N.,Chen, Z.W.,Pineda, A.O.,Mathews, F.S.,Di Cera, E.,Giardino, E.C.,Wells, G.I.,Haertlein, B.J.,Kauffman, J.A.,Corcoran, T.W.,Derian, C.K.,Eckardt, A.J.,Damiano, B.P.,Andrade-Gordon, P.,Maryanoff, B.E. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J.Biol.Chem., 280:18001-18007, 2005 Cited by PubMed: 15741158 DOI: 10.1074/jbc.M501302200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation