8VSU
 
 | | Cryo-EM structure of LKB1-STRADalpha-MO25alpha heterocomplex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Calcium-binding protein 39, Isoform 3 of STE20-related kinase adapter protein alpha, ... | | Authors: | Chan, L.M, Courteau, B.J, Verba, K.A. | | Deposit date: | 2024-01-24 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | High-resolution single-particle imaging at 100-200 keV with the Gatan Alpine direct electron detector.
J.Struct.Biol., 216, 2024
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6OMV
 | | CryoEM structure of the LbCas12a-crRNA-AcrVA4-DNA complex | | Descriptor: | AcrVA4, Cpf1, DNA (5'-D(*CP*GP*TP*CP*CP*TP*TP*TP*AP*GP*GP*A)-3'), ... | | Authors: | Chang, L, Li, Z, Zhang, H. | | Deposit date: | 2019-04-19 | | Release date: | 2019-06-12 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins.
Cell Host Microbe, 25, 2019
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8UDR
 | | Structure of the P1B7 antibody bound to the Sotorasib-modified KRas G12C peptide presented by the A*03:01 MHC I complex | | Descriptor: | AMG 510 (bound form), Beta-2-microglobulin, GTPase KRas, ... | | Authors: | Chan, L.M, Roweder, P.J, Craik, C.S, Verba, K.A. | | Deposit date: | 2023-09-28 | | Release date: | 2024-10-16 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Therapeutic Targeting and Structural Characterization of a Sotorasib-Modified KRAS G12C-MHC I Complex Demonstrate the Antitumor Efficacy of Hapten-Based Strategies.
Cancer Res., 85, 2025
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6WN1
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6WTU
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6WQO
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6WOZ
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6WTY
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6WNO
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6WTV
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6WM9
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7K7X
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8V32
 | | TnsD-TnsC-DNA complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (41-MER), MAGNESIUM ION, ... | | Authors: | Chang, L, Wang, S. | | Deposit date: | 2023-11-26 | | Release date: | 2024-10-16 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition.
Cell, 187, 2024
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6UVN
 | | CryoEM structure of VcCascasde-TniQ complex | | Descriptor: | Cas6, Cas7, Cas8/5, ... | | Authors: | Chang, L, Li, Z, Zhang, H. | | Deposit date: | 2019-11-03 | | Release date: | 2020-01-29 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of a type I-F CRISPR RNA guided surveillance complex bound to transposition protein TniQ.
Cell Res., 30, 2020
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4UI9
 | | Atomic structure of the human Anaphase-Promoting Complex | | Descriptor: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | | Authors: | Chang, L, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | | Deposit date: | 2015-03-27 | | Release date: | 2015-06-17 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination
Nature, 522, 2015
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6FX0
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6TGB
 | | CryoEM structure of the binary DOCK2-ELMO1 complex | | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | Deposit date: | 2019-11-15 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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6TGC
 | | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | | Deposit date: | 2019-11-15 | | Release date: | 2020-07-29 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Nat Commun, 11, 2020
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7JZZ
 | | Cryo-EM structure of CRISPR-Cas surveillance complex with AcrIF14 | | Descriptor: | AcrF14, CRISPR type I-F/YPEST-associated protein Csy3, CRISPR-associated protein Csy1, ... | | Authors: | Chang, L, Li, Z, Gabel, C. | | Deposit date: | 2020-09-02 | | Release date: | 2020-12-30 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4, AcrIF7 and AcrIF14.
Nucleic Acids Res., 49, 2021
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7JZY
 | | CryoEM structure of a CRISPR-Cas complex | | Descriptor: | AcrF9, CRISPR type I-F/YPEST-associated protein Csy3, CRISPR-associated protein Csy1, ... | | Authors: | Chang, L, Li, Z, Gabel, C. | | Deposit date: | 2020-09-02 | | Release date: | 2021-09-22 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | CryoEM structure of a CRISPR-Cas complex
To Be Published
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6XMG
 | | Cryo-EM structure of Cas12g ternary complex | | Descriptor: | CRISPR-Cas, RNA (130-MER), RNA (5'-R(P*UP*UP*AP*AP*UP*GP*CP*GP*GP*UP*AP*GP*UP*UP*UP*AP*UP*CP*AP*CP*AP*GP*UP*U)-3'), ... | | Authors: | Chang, L, Li, Z, Zhang, H. | | Deposit date: | 2020-06-30 | | Release date: | 2021-01-13 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Cryo-EM structure of the RNA-guided ribonuclease Cas12g.
Nat.Chem.Biol., 17, 2021
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7JZX
 | | Cryo-EM structure of CRISPR-Cas surveillance complex with AcrIF7 | | Descriptor: | AcrF7, CRISPR type I-F/YPEST-associated protein Csy3, CRISPR-associated endonuclease Cas6/Csy4, ... | | Authors: | Chang, L, Li, Z, Gabel, C. | | Deposit date: | 2020-09-02 | | Release date: | 2020-12-30 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4, AcrIF7 and AcrIF14.
Nucleic Acids Res., 49, 2021
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7JZW
 | | Cryo-EM structure of CRISPR-Cas surveillance complex with AcrIF4 | | Descriptor: | CRISPR repeat sequence, CRISPR type I-F/YPEST-associated protein Csy1, CRISPR type I-F/YPEST-associated protein Csy2, ... | | Authors: | Chang, L, Li, Z, Gabel, C. | | Deposit date: | 2020-09-02 | | Release date: | 2020-12-30 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for inhibition of the type I-F CRISPR-Cas surveillance complex by AcrIF4, AcrIF7 and AcrIF14.
Nucleic Acids Res., 49, 2021
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7L49
 | | Cryo-EM structure of CRISPR-Cas12f Ternary Complex | | Descriptor: | Cas12f1, NTS, Substrate, ... | | Authors: | Chang, L, Li, Z. | | Deposit date: | 2020-12-18 | | Release date: | 2021-06-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease.
Nucleic Acids Res., 49, 2021
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7L48
 | | Cryo-EM structure of a CRISPR-Cas12f Binary Complex | | Descriptor: | Cas12f, ZINC ION, sgRNA | | Authors: | Chang, L, Li, Z. | | Deposit date: | 2020-12-18 | | Release date: | 2021-06-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR-Cas12f nuclease.
Nucleic Acids Res., 49, 2021
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