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PDB: 73 results

6OM7
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BU of 6om7 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-18
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLG
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BU of 6olg by Molmil
Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLF
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BU of 6olf by Molmil
Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OM0
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BU of 6om0 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
8G6X
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BU of 8g6x by Molmil
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe
Descriptor: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminobenzamide, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-03-22
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.31 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8G6W
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BU of 8g6w by Molmil
Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe
Descriptor: 16S rRNA, 2-AMINO-BENZAMIDE, 23S rRNA, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-04-05
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.02 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
8G6Y
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BU of 8g6y by Molmil
Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe
Descriptor: 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), 3-aminopyridine-4-carboxamide, ...
Authors:Majumdar, C, Cate, J.H.D.
Deposit date:2023-02-16
Release date:2023-04-05
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.09 Å)
Cite:Aminobenzoic Acid Derivatives Obstruct Induced Fit in the Catalytic Center of the Ribosome.
Acs Cent.Sci., 9, 2023
4V42
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BU of 4v42 by Molmil
Crystal structure of the ribosome at 5.5 A resolution.
Descriptor: 30S 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Yusupov, M.M, Yusupova, G.Z, Baucom, A, Lieberman, K, Earnest, T.N, Cate, J.H.D, Noller, H.F.
Deposit date:2001-03-30
Release date:2014-07-09
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Crystal structure of the ribosome at 5.5 A resolution
Science, 292, 2001
4V4H
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BU of 4v4h by Molmil
Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.
Descriptor: (1S,2R,3S,4R,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL 2-AMINO-4-{[CARBOXY(IMINO)METHYL]AMINO}-2,3,4,6-TETRADEOXY-ALPHA-D-ARABINO-HEXOPYRANOSIDE, 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, ...
Authors:Schuwirth, B.S, Vila-Sanjurjo, A, Cate, J.H.D.
Deposit date:2006-08-04
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Structural analysis of kasugamycin inhibition of translation.
Nat.Struct.Mol.Biol., 13, 2006
8EIU
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BU of 8eiu by Molmil
E. coli 70S ribosome with A-loop mutations U2554C and U2555C
Descriptor: 16S rRNA, 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ...
Authors:Nissley, A.J, Penev, P.I, Watson, Z.L, Banfield, J.F, Cate, J.H.D.
Deposit date:2022-09-15
Release date:2023-02-01
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.24 Å)
Cite:Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome.
Nucleic Acids Res., 51, 2023
8EMM
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BU of 8emm by Molmil
Composite 70S ribosome structure for "Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Watson, Z.L, Cate, J.H.D.
Deposit date:2022-09-28
Release date:2023-05-31
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates.
Nat.Chem., 15, 2023
8FTO
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BU of 8fto by Molmil
E. coli 70S ribosome with an improved MS2 tag inserted in H98
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Nissley, A.J, Cate, J.H.D.
Deposit date:2023-01-12
Release date:2023-08-02
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (1.85 Å)
Cite:Interactions between terminal ribosomal RNA helices stabilize the E. coli large ribosomal subunit.
Rna, 29, 2023
4YBB
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BU of 4ybb by Molmil
High-resolution structure of the Escherichia coli ribosome
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ...
Authors:Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D.
Deposit date:2015-02-18
Release date:2015-03-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution structure of the Escherichia coli ribosome.
Nat.Struct.Mol.Biol., 22, 2015
4V6E
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BU of 4v6e by Molmil
Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Zhang, W, Dunkle, J.A, Cate, J.H.D.
Deposit date:2009-06-28
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.712 Å)
Cite:Structures of the ribosome in intermediate States of ratcheting.
Science, 325, 2009
4V5Y
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BU of 4v5y by Molmil
Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D.
Deposit date:2007-06-19
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4.45 Å)
Cite:Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.
Nat.Struct.Mol.Biol., 14, 2007
4V7S
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BU of 4v7s by Molmil
Crystal structure of the E. coli ribosome bound to telithromycin.
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D.
Deposit date:2010-08-05
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2547 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V9O
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BU of 4v9o by Molmil
Control of ribosomal subunit rotation by elongation factor G
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Pulk, A, Cate, J.H.D.
Deposit date:2013-05-03
Release date:2014-07-09
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Control of ribosomal subunit rotation by elongation factor G.
Science, 340, 2013
4V53
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BU of 4v53 by Molmil
Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.
Descriptor: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ...
Authors:Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D.
Deposit date:2007-06-16
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.
Nat.Struct.Mol.Biol., 14, 2007
4V6D
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BU of 4v6d by Molmil
Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Zhang, W, Dunkle, J.A, Cate, J.H.D.
Deposit date:2009-06-27
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3.814 Å)
Cite:Structures of the ribosome in intermediate States of ratcheting.
Science, 325, 2009
4V56
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BU of 4v56 by Molmil
Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Borovinskaya, M.A, Shoji, S, Holton, J.M, Fredrick, K, Cate, J.H.D.
Deposit date:2007-07-21
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.93 Å)
Cite:A steric block in translation caused by the antibiotic spectinomycin.
Acs Chem.Biol., 2, 2007
4V55
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BU of 4v55 by Molmil
Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).
Descriptor: (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ...
Authors:Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D.
Deposit date:2007-06-17
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural basis for aminoglycoside inhibition of bacterial ribosome recycling.
Nat.Struct.Mol.Biol., 14, 2007
4V7U
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BU of 4v7u by Molmil
Crystal structure of the E. coli ribosome bound to erythromycin.
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D.
Deposit date:2010-08-15
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V9P
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BU of 4v9p by Molmil
Control of ribosomal subunit rotation by elongation factor G
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Pulk, A, Cate, J.H.D.
Deposit date:2013-05-03
Release date:2014-07-09
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Control of ribosomal subunit rotation by elongation factor G.
Science, 340, 2013
4V7T
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BU of 4v7t by Molmil
Crystal structure of the E. coli ribosome bound to chloramphenicol.
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D.
Deposit date:2010-08-14
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1942 Å)
Cite:Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V49
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BU of 4v49 by Molmil
Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.
Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S ribosomal protein S10, ...
Authors:Vila-Sanjurjo, A, Ridgeway, W.K, Seymaner, V, Zhang, W, Santoso, S, Yu, K, Cate, J.H.D.
Deposit date:2003-06-13
Release date:2014-07-09
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (8.7 Å)
Cite:X-ray Crystal Structures of the WT and a Hyper-Accurate Ribosome From Escherichia Coli
Proc.Natl.Acad.Sci.USA, 100, 2003

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