Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 382 results

4D49
DownloadVisualize
BU of 4d49 by Molmil
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.
Descriptor: ARGININE, ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE
Authors:Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A.
Deposit date:2014-10-27
Release date:2016-01-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
5OWA
DownloadVisualize
BU of 5owa by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with BZ054
Descriptor: Peregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-08-31
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018
5OV8
DownloadVisualize
BU of 5ov8 by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with BZ097
Descriptor: NITRATE ION, Peregrin, ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-pyrrolidin-1-yl-quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-08-28
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018
5OWW
DownloadVisualize
BU of 5oww by Molmil
Crystal structure of human BRD4(1) bromodomain in complex with UT22B
Descriptor: Bromodomain-containing protein 4, ~{N}-(3-methylbenzotriazol-5-yl)-1-(phenylmethyl)imidazole-2-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-09-04
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).
Acs Cent.Sci., 4, 2018
5OR8
DownloadVisualize
BU of 5or8 by Molmil
Crystal Structure of BAZ2A bromodomain in complex with 1,3-dimethyl-benzimidazolone compound 1
Descriptor: Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[(4-fluorophenyl)methyl]-1,3,6-trimethyl-2-oxidanylidene-benzimidazole-5-sulfonamide
Authors:Lolli, G, Dalle Vedove, A, Marchand, J.-R, Caflisch, A.
Deposit date:2017-08-15
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.
J Chem Inf Model, 57, 2017
5OVB
DownloadVisualize
BU of 5ovb by Molmil
Crystal structure of human BRD4(1) bromodomain in complex with DR46
Descriptor: Bromodomain-containing protein 4, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(1-methylpyrazol-3-yl)phenyl]furan-2-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-08-28
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).
Acs Cent.Sci., 4, 2018
5OWK
DownloadVisualize
BU of 5owk by Molmil
Crystal structure of CREBBP bromodomain complexed with DSPB2A002
Descriptor: CREB-binding protein, ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate
Authors:Zhu, J, Spiliotopoulos, D, Caflisch, A.
Deposit date:2017-09-01
Release date:2018-08-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5OWM
DownloadVisualize
BU of 5owm by Molmil
Crystal structure of human BRD4(1) bromodomain in complex with UT48
Descriptor: Bromodomain-containing protein 4, [3-[(3-methylbenzotriazol-5-yl)methyl]phenyl]methanol
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-09-01
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).
Acs Cent.Sci., 4, 2018
2MUS
DownloadVisualize
BU of 2mus by Molmil
HADDOCK calculated model of LIN5001 bound to the HET-s amyloid
Descriptor: 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Heterokaryon incompatibility protein s
Authors:Hermann, U.S, Schuetz, A.K, Shirani, H, Saban, D, Nuvolone, M, Huang, D.H, Li, B, Ballmer, B, Aslund, A.K.O, Mason, J.J, Rushing, E, Budka, H, Hammarstrom, P, Bockmann, A, Caflisch, A, Meier, B.H, Nilsson, P.K.R, Hornemann, S, Aguzzi, A.
Deposit date:2014-09-16
Release date:2017-02-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure-based drug design identifies polythiophenes as antiprion compounds.
Sci Transl Med, 7, 2015
4GK4
DownloadVisualize
BU of 4gk4 by Molmil
Human EphA3 Kinase domain in complex with ligand 90
Descriptor: 8-butyl-1-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3
Authors:Dong, J, Caflisch, A.
Deposit date:2012-08-10
Release date:2013-01-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
4GK3
DownloadVisualize
BU of 4gk3 by Molmil
Human EphA3 Kinase domain in complex with ligand 87
Descriptor: 8-butyl-1-methyl-7-(2-methylphenyl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3
Authors:Dong, J, Caflisch, A.
Deposit date:2012-08-10
Release date:2013-01-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
4GK2
DownloadVisualize
BU of 4gk2 by Molmil
Human EphA3 Kinase domain in complex with ligand 66
Descriptor: 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, EPH receptor A3
Authors:Dong, J, Caflisch, A.
Deposit date:2012-08-10
Release date:2013-01-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.195 Å)
Cite:Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography.
J.Med.Chem., 56, 2013
6EPT
DownloadVisualize
BU of 6ept by Molmil
The ATAD2 bromodomain in complex with compound 12
Descriptor: (2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]piperazine-2-carboxamide, (2~{S})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]piperazine-2-carboxamide, ATPase family AAA domain-containing protein 2, ...
Authors:Sledz, P, Caflisch, A.
Deposit date:2017-10-12
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11, 2020
5OR9
DownloadVisualize
BU of 5or9 by Molmil
Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 13
Descriptor: (2~{S})-1-(4-fluorophenyl)sulfonyl-~{N}-(2-methyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Lolli, G, Vedove, A.D, Marchand, J.-R, Caflisch, A.
Deposit date:2017-08-15
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.
J Chem Inf Model, 57, 2017
6EPJ
DownloadVisualize
BU of 6epj by Molmil
The ATAD2 bromodomain in complex with compound 6
Descriptor: (2~{R})-2-azanyl-~{N}-[4-ethanoyl-5-(3-hydroxyphenyl)-1,3-thiazol-2-yl]propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION
Authors:Sledz, P, Caflisch, A.
Deposit date:2017-10-11
Release date:2018-10-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.652 Å)
Cite:Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11, 2020
5ORB
DownloadVisualize
BU of 5orb by Molmil
Crystal Structure of BAZ2B bromodomain in complex with 1-methyl-cyclopentapyrazole compound 30
Descriptor: 1,2-ETHANEDIOL, 2-(4-methoxyphenyl)sulfanyl-~{N}-(2-methyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)ethanamide, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Lolli, G, Dalle Vedove, A, Marchand, J.-R, Caflisch, A.
Deposit date:2017-08-15
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking.
J Chem Inf Model, 57, 2017
6EKQ
DownloadVisualize
BU of 6ekq by Molmil
Crystal structure of the human BRPF1 bromodomain complexed with BZ054 in space group C2
Descriptor: NITRATE ION, Peregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide
Authors:Zhu, J, Caflisch, A.
Deposit date:2017-09-26
Release date:2018-06-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018
6EPV
DownloadVisualize
BU of 6epv by Molmil
The ATAD2 bromodomain in complex with compound 5
Descriptor: (2~{R})-2-azanyl-~{N}-(4-oxidanylidene-6,7-dihydro-5~{H}-1,3-benzothiazol-2-yl)propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION
Authors:Sledz, P, Caflisch, A.
Deposit date:2017-10-12
Release date:2018-10-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11, 2020
6QST
DownloadVisualize
BU of 6qst by Molmil
Structure of CREBBP bromodomain with compound 2 bound
Descriptor: CREB-binding protein, ~{N}-[3-(3-azanyl-5-methyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
Authors:Zhu, J, Sledz, P, Caflisch, A.
Deposit date:2019-02-22
Release date:2020-03-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of CREBBP bromodomain with compound 2 bound
To Be Published
6EPX
DownloadVisualize
BU of 6epx by Molmil
The ATAD2 bromodomain in complex with compound 3
Descriptor: (2~{R})-2-carbamimidamido-~{N}-(4-ethanoyl-1,3-thiazolidin-2-yl)propanamide, ATPase family AAA domain-containing protein 2, SULFATE ION
Authors:Sledz, P, Caflisch, A.
Deposit date:2017-10-12
Release date:2018-10-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11, 2020
4PCE
DownloadVisualize
BU of 4pce by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with compound B13
Descriptor: 1,2-ETHANEDIOL, 1-benzyl-2-ethyl-1,5,6,7-tetrahydro-4H-indol-4-one, Bromodomain-containing protein 4
Authors:Dong, J, Caflisch, A.
Deposit date:2014-04-15
Release date:2014-05-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.293 Å)
Cite:Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking.
Bioorg.Med.Chem.Lett., 24, 2014
4G2F
DownloadVisualize
BU of 4g2f by Molmil
Human EphA3 kinase domain in complex with compound 7
Descriptor: 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5H)-one, EPH receptor A3
Authors:Dong, J, Caflisch, A.
Deposit date:2012-07-12
Release date:2012-10-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.699 Å)
Cite:Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.
ACS MED.CHEM.LETT., 3, 2012
5L97
DownloadVisualize
BU of 5l97 by Molmil
Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 3
Descriptor: 2-methyl-~{N}-[(2~{S})-2-methylsulfonylcyclopentyl]pyridin-3-amine, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Lolli, G, Marchand, J.-R, Caflisch, A.
Deposit date:2016-06-09
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.
J. Med. Chem., 59, 2016
5L96
DownloadVisualize
BU of 5l96 by Molmil
Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 1
Descriptor: 1,2-ETHANEDIOL, 2-methyl-~{N}-[(2~{R})-1-methylsulfonylpropan-2-yl]pyridin-3-amine, Bromodomain adjacent to zinc finger domain protein 2B
Authors:Lolli, G, Marchand, J.-R, Caflisch, A.
Deposit date:2016-06-09
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.
J. Med. Chem., 59, 2016
5L8T
DownloadVisualize
BU of 5l8t by Molmil
Crystal Structure of BAZ2B bromodomain in complex with 3-amino-2-methylpyridine derivative 2
Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, ~{N}-[(3~{R})-1,1-bis(oxidanylidene)thian-3-yl]-2-methyl-pyridin-3-amine
Authors:Lolli, G, Marchand, J.-R, Caflisch, A.
Deposit date:2016-06-08
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Derivatives of 3-Amino-2-methylpyridine as BAZ2B Bromodomain Ligands: In Silico Discovery and in Crystallo Validation.
J. Med. Chem., 59, 2016

226707

건을2024-10-30부터공개중

PDB statisticsPDBj update infoContact PDBjnumon