5OWA

Crystal structure of the human BRPF1 bromodomain in complex with BZ054

Summary for 5OWA

Entry DOI	10.2210/pdb5owa/pdb
Descriptor	Peregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (3 entities in total)
Functional Keywords	bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	55860.18
Authors	Zhu, J.,Caflisch, A. (deposition date: 2017-08-31, release date: 2018-06-27, Last modification date: 2024-01-17)
Primary citation	Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720 DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation