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6EKQ

Crystal structure of the human BRPF1 bromodomain complexed with BZ054 in space group C2

Summary for 6EKQ
Entry DOI10.2210/pdb6ekq/pdb
DescriptorPeregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide, NITRATE ION, ... (4 entities in total)
Functional Keywordsbromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight28228.33
Authors
Zhu, J.,Caflisch, A. (deposition date: 2017-09-26, release date: 2018-06-27, Last modification date: 2024-01-17)
Primary citationZhu, J.,Zhou, C.,Caflisch, A.
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155:337-352, 2018
Cited by
PubMed: 29902720
DOI: 10.1016/j.ejmech.2018.05.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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