6EKQ
Crystal structure of the human BRPF1 bromodomain complexed with BZ054 in space group C2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peregrin | polymer | 116 | 13703.7 | 2 | UniProt (P55201) Pfam (PF00439) | Homo sapiens (Human) | Bromodomain and PHD finger-containing protein 1,Protein Br140 |
| 2 | C, F (A, B) | ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide | non-polymer | 348.5 | 2 | Chemie (B0H) | |||
| 3 | D, E (A) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 418 | Chemie (HOH) |
Sequence modifications
A, B: 626 - 740 (UniProt: P55201)
| PDB | External Database | Details |
|---|---|---|
| Ser 625 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27407.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 820.9 | |
| All* | Total formula weight | 28228.3 |
