5OR8
Crystal Structure of BAZ2A bromodomain in complex with 1,3-dimethyl-benzimidazolone compound 1
Summary for 5OR8
| Entry DOI | 10.2210/pdb5or8/pdb |
| Descriptor | Bromodomain adjacent to zinc finger domain protein 2A, ~{N}-[(4-fluorophenyl)methyl]-1,3,6-trimethyl-2-oxidanylidene-benzimidazole-5-sulfonamide (3 entities in total) |
| Functional Keywords | four helical bundle, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus, nucleolus : Q9UIF9 |
| Total number of polymer chains | 1 |
| Total formula weight | 12872.45 |
| Authors | Lolli, G.,Dalle Vedove, A.,Marchand, J.-R.,Caflisch, A. (deposition date: 2017-08-15, release date: 2017-09-13, Last modification date: 2024-01-17) |
| Primary citation | Marchand, J.R.,Dalle Vedove, A.,Lolli, G.,Caflisch, A. Discovery of Inhibitors of Four Bromodomains by Fragment-Anchored Ligand Docking. J Chem Inf Model, 57:2584-2597, 2017 Cited by PubMed: 28862840DOI: 10.1021/acs.jcim.7b00336 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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