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PDB: 112 results

8ONP
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BU of 8onp by Molmil
Human insulin trans-HypB26-DTIA analogue
Descriptor: Insulin A chain, Insulin B chain, SULFATE ION
Authors:Brzozowski, A.M, Zakova, L, Jiracek, J.
Deposit date:2023-04-03
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Analogues of human insulin with specificity to insulin receptor isoform B
To Be Published
8OKY
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BU of 8oky by Molmil
Crystal structure of D-ProB26-DTriA analogue of human insulin
Descriptor: Insulin A chain, Insulin B chain
Authors:Brzozowski, A.M, Zakova, L, Jiracek, J.
Deposit date:2023-03-29
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Analogues of human insulin with specificity to insulin receptor isoform B
To Be Published
8ONR
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BU of 8onr by Molmil
Crystal structure of human insulin trans-HypB26-DTI analogue
Descriptor: Insulin A chain, Insulin B chain, PHENOL, ...
Authors:Brzozowski, A.M, Zakova, L, Jiracek, J.
Deposit date:2023-04-03
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of human insulin trans-HypB26-DTI analogue
To Be Published
5TGL
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BU of 5tgl by Molmil
A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX
Descriptor: LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER
Authors:Brzozowski, A.M, Derewenda, U, Derewenda, Z.S, Dodson, G.G, Lawson, D, Turkenburg, J.P, Bjorkling, F, Huge-Jensen, B, Patkar, S.R, Thim, L.
Deposit date:1991-10-30
Release date:1994-01-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex.
Nature, 351, 1991
6FF3
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BU of 6ff3 by Molmil
Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I
Descriptor: Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2
Authors:Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M.
Deposit date:2018-01-03
Release date:2018-09-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Nat Commun, 9, 2018
6FEY
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BU of 6fey by Molmil
Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin
Descriptor: Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5
Authors:Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D.
Deposit date:2018-01-03
Release date:2018-09-26
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.48 Å)
Cite:Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones.
Nat Commun, 9, 2018
5MAM
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BU of 5mam by Molmil
Human insulin in complex with serotonin
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2016-11-03
Release date:2017-04-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
5MT9
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BU of 5mt9 by Molmil
Human insulin in complex with serotonin and arginine
Descriptor: ARGININE, CHLORIDE ION, Insulin, ...
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2017-01-07
Release date:2017-04-05
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
5MT3
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BU of 5mt3 by Molmil
Human insulin in complex with serotonin and arginine
Descriptor: ARGININE, CHLORIDE ION, Insulin, ...
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2017-01-06
Release date:2017-04-05
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules.
J. Biol. Chem., 292, 2017
5BQQ
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BU of 5bqq by Molmil
Human insulin with intra-chain chemical crosslink between modified B27 and B30
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2015-05-29
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
5BOQ
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BU of 5boq by Molmil
Human insulin with intra-chain chemical crosslink between modified B24 and B29
Descriptor: Insulin, SULFATE ION
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2015-05-27
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
5BPO
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BU of 5bpo by Molmil
Human insulin with intra-chain chemical crosslink between modified B27 and B29
Descriptor: Insulin
Authors:Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L.
Deposit date:2015-05-28
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational steering of insulin binding specificity by intra-chain chemical crosslinking.
Sci Rep, 6, 2016
2WRX
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BU of 2wrx by Molmil
Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRW
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BU of 2wrw by Molmil
Semi-synthetic highly active analogue of human insulin D-ProB26-DTI- NH2
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS6
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BU of 2ws6 by Molmil
Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form
Descriptor: CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ...
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRV
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BU of 2wrv by Molmil
Semi-synthetic highly active analogue of human insulin NMeHisB26-DTI- NH2
Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS4
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BU of 2ws4 by Molmil
Semi-synthetic analogue of human insulin ProB26-DTI in monomer form
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS0
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BU of 2ws0 by Molmil
Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WRU
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BU of 2wru by Molmil
Semi-synthetic highly active analogue of human insulin NMeAlaB26-DTI- NH2
Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-02
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS7
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BU of 2ws7 by Molmil
Semi-synthetic analogue of human insulin ProB26-DTI
Descriptor: CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ...
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WS1
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BU of 2ws1 by Molmil
Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form
Descriptor: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN
Authors:Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G.
Deposit date:2009-09-03
Release date:2010-02-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107, 2010
1E43
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BU of 1e43 by Molmil
Native structure of chimaeric amylase from B. amyloliquefaciens and B. licheniformis at 1.7A
Descriptor: ALPHA-AMYLASE, CALCIUM ION, SODIUM ION
Authors:Brzozowski, A.M, Lawson, D.M, Turkenburg, J.P, Bisgaard-Frantzen, H, Svendsen, A, Borchert, T.V, Dauter, Z, Wilson, K.S, Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E40
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BU of 1e40 by Molmil
Tris/maltotriose complex of chimaeric amylase from B. amyloliquefaciens and B. licheniformis at 2.2A
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALPHA-AMYLASE, CALCIUM ION, ...
Authors:Brzozowski, A.M, Lawson, D.M, Turkenburg, J.P, Bisgaard-Frantzen, H, Svendsen, A, Borchert, T.V, Dauter, Z, Wilson, K.S, Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E3X
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BU of 1e3x by Molmil
Native structure of chimaeric amylase from B. amyloliquefaciens and B. licheniformis at 1.92A
Descriptor: ALPHA-AMYLASE, CALCIUM ION, SODIUM ION
Authors:Brzozowski, A.M, Lawson, D.M, Turkenburg, J.P, Bisgaard-Frantzen, H, Svendsen, A, Borchert, T.V, Dauter, Z, Wilson, K.S, Davies, G.J.
Deposit date:2000-06-26
Release date:2001-06-21
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000
1E3Z
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BU of 1e3z by Molmil
Acarbose complex of chimaeric amylase from B. amyloliquefaciens and B. licheniformis at 1.93A
Descriptor: 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-alpha-D-glucopyranose, 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Brzozowski, A.M, Lawson, D.M, Turkenburg, J.P, Bisgaard-Frantzen, H, Svendsen, A, Borchert, T.V, Dauter, Z, Wilson, K.S, Davies, G.J.
Deposit date:2000-06-27
Release date:2001-06-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Analysis of a Chimeric Bacterial Alpha-Amylase. High Resolution Analysis of Native and Ligand Complexes
Biochemistry, 39, 2000

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