8ONP
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8ONR
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8OKY
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5TGL
| A MODEL FOR INTERFACIAL ACTIVATION IN LIPASES FROM THE STRUCTURE OF A FUNGAL LIPASE-INHIBITOR COMPLEX | 分子名称: | LIPASE, N-HEXYLPHOSPHONATE ETHYL ESTER | 著者 | Brzozowski, A.M, Derewenda, U, Derewenda, Z.S, Dodson, G.G, Lawson, D, Turkenburg, J.P, Bjorkling, F, Huge-Jensen, B, Patkar, S.R, Thim, L. | 登録日 | 1991-10-30 | 公開日 | 1994-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex. Nature, 351, 1991
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5MAM
| Human insulin in complex with serotonin | 分子名称: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | 登録日 | 2016-11-03 | 公開日 | 2017-04-05 | 最終更新日 | 2017-05-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
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5MT9
| Human insulin in complex with serotonin and arginine | 分子名称: | ARGININE, CHLORIDE ION, Insulin, ... | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | 登録日 | 2017-01-07 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
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5MT3
| Human insulin in complex with serotonin and arginine | 分子名称: | ARGININE, CHLORIDE ION, Insulin, ... | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | 登録日 | 2017-01-06 | 公開日 | 2017-04-05 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules. J. Biol. Chem., 292, 2017
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6FEY
| Crystal structure of Drosophila neural ectodermal development factor Imp-L2 with Drosophila DILP5 insulin | 分子名称: | Neural/ectodermal development factor IMP-L2, Probable insulin-like peptide 5 | 著者 | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D. | 登録日 | 2018-01-03 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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6FF3
| Crystal structure of Drosophila neural ectodermal development factor Imp-L1 with Human IGF-I | 分子名称: | Insulin-like growth factor I, Neural/ectodermal development factor IMP-L2 | 著者 | Brzozowski, A.M, Kulahin, N, Kristensen, O, Schluckebier, G, Meyts, P.D, Viola, C.M. | 登録日 | 2018-01-03 | 公開日 | 2018-09-26 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones. Nat Commun, 9, 2018
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5BQQ
| Human insulin with intra-chain chemical crosslink between modified B27 and B30 | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | 登録日 | 2015-05-29 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
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2WS1
| Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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5BOQ
| Human insulin with intra-chain chemical crosslink between modified B24 and B29 | 分子名称: | Insulin, SULFATE ION | 著者 | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | 登録日 | 2015-05-27 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
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2WS7
| Semi-synthetic analogue of human insulin ProB26-DTI | 分子名称: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS4
| Semi-synthetic analogue of human insulin ProB26-DTI in monomer form | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS0
| Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 7.5 | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRX
| Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-02 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRU
| Semi-synthetic highly active analogue of human insulin NMeAlaB26-DTI- NH2 | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-02 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRV
| Semi-synthetic highly active analogue of human insulin NMeHisB26-DTI- NH2 | 分子名称: | ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-02 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WRW
| Semi-synthetic highly active analogue of human insulin D-ProB26-DTI- NH2 | 分子名称: | INSULIN A CHAIN, INSULIN B CHAIN | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-02 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS6
| Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form | 分子名称: | CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... | 著者 | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | 登録日 | 2009-09-03 | 公開日 | 2010-02-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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5BPO
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1H02
| Human Insulin-like growth factor; SRS Daresbury data | 分子名称: | INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE | 著者 | Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. | 登録日 | 2002-06-11 | 公開日 | 2002-07-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
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1GZZ
| Human Insulin-like growth factor; Hamburg data | 分子名称: | INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE | 著者 | Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. | 登録日 | 2002-06-10 | 公開日 | 2002-07-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
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1GZR
| Human Insulin-like growth factor; ESRF data | 分子名称: | INSULIN-LIKE GROWTH FACTOR I, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE | 著者 | Brzozowski, A.M, Dodson, E.J, Dodson, G.G, Murshudov, G, Verma, C, Turkenburg, J.P, De Bree, F.M, Dauter, Z. | 登録日 | 2002-05-28 | 公開日 | 2002-07-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin Biochemistry, 41, 2002
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1GT6
| S146A mutant of Thermomyces (Humicola) lanuginosa lipase complex with oleic acid | 分子名称: | Lipase, OLEIC ACID | 著者 | Brzozowski, A.M, Yapoudjian, S, Ivanova, M.G, Patkar, S.A, Vind, J, Svendsen, A, Verger, R. | 登録日 | 2002-01-11 | 公開日 | 2003-01-23 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC. Eur.J.Biochem., 269, 2002
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