2GN5
| |
2CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-08 | 公開日 | 2001-06-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
|
|
3CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-08 | 公開日 | 2001-06-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
|
|
1CPU
| SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-amino-4,6-dideoxy-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, ... | 著者 | Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G. | 登録日 | 1999-06-07 | 公開日 | 1999-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques. Biochemistry, 39, 2000
|
|
4W93
| Human pancreatic alpha-amylase in complex with montbretin A | 分子名称: | CALCIUM ION, CHLORIDE ION, Montbretin A, ... | 著者 | Williams, L.K, Caner, S, Brayer, G.D. | 登録日 | 2014-08-27 | 公開日 | 2015-07-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.352 Å) | 主引用文献 | The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif. Nat.Chem.Biol., 11, 2015
|
|
2YCC
| |
5VA9
| |
2ALP
| REFINED STRUCTURE OF ALPHA-LYTIC PROTEASE AT 1.7 ANGSTROMS RESOLUTION. ANALYSIS OF HYDROGEN BONDING AND SOLVENT STRUCTURE | 分子名称: | ALPHA-LYTIC PROTEASE, SULFATE ION | 著者 | Fujinaga, M, Delbaere, L.T.J, Brayer, G.D, James, M.N.G. | 登録日 | 1985-03-07 | 公開日 | 1985-07-17 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure. J.Mol.Biol., 184, 1985
|
|
6DV5
| |
1AZI
| |
4X0N
| |
4X9Y
| |
5KEZ
| |
4YVA
| Cathepsin K co-crystallized with actinomycetes extract | 分子名称: | Cathepsin K, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
|
|
4N79
| Structure of Cathepsin K-dermatan sulfate complex | 分子名称: | Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2013-10-15 | 公開日 | 2014-11-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4N8W
| cathepsin K - chondroitin sulfate complex | 分子名称: | 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Cathepsin K | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2013-10-18 | 公開日 | 2014-11-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4YV8
| Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal | 分子名称: | Cathepsin K, Lichostatinal, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
|
|
6OBX
| |
6OCN
| |
6PXF
| Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution | 分子名称: | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid, Cathepsin K | 著者 | Law, S, Aguda, A.H, Nguyen, N.T, Brayer, G.D, Bromme, D. | 登録日 | 2019-07-25 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution To Be Published
|
|
3ZOA
| The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis in complex with acarbose | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | 著者 | Caner, S, Nguyen, N, Aguda, A, Zhang, R, Pan, Y.T, Withers, S.G, Brayer, G.D. | 登録日 | 2013-02-21 | 公開日 | 2013-07-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The Structure of the Mycobacterium Smegmatis Trehalose Synthase Reveals an Unusual Active Site Configuration and Acarbose-Binding Mode. Glycobiology, 23, 2013
|
|
3ZO9
| The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis | 分子名称: | CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Caner, S, Nguyen, N, Aguda, A, Zhang, R, Pan, Y.T, Withers, S.G, Brayer, G.D. | 登録日 | 2013-02-21 | 公開日 | 2013-07-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | The Structure of the Mycobacterium Smegmatis Trehalose Synthase Reveals an Unusual Active Site Configuration and Acarbose-Binding Mode. Glycobiology, 23, 2013
|
|
3IJ8
| Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, 5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-04 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
|
|
3IJ7
| Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | 4-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosyl fluoride, 4-O-methyl-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-2)-5-fluoro-alpha-L-idopyranose, CALCIUM ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-03 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
|
|
3IJ9
| Directed 'in situ' Elongation as a Strategy to Characterize the Covalent Glycosyl-Enzyme Catalytic Intermediate of Human Pancreatic a-Amylase | 分子名称: | (2R,3S,4R,5R,6R)-2,6-difluoro-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, CALCIUM ION, CHLORIDE ION, ... | 著者 | Li, C, Zhang, R, Withers, S.G, Brayer, G.D. | 登録日 | 2009-08-04 | 公開日 | 2009-10-27 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Directed "in situ" inhibitor elongation as a strategy to structurally characterize the covalent glycosyl-enzyme intermediate of human pancreatic alpha-amylase Biochemistry, 48, 2009
|
|