3ZOA

The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis in complex with acarbose

Summary for 3ZOA

• Entry DOI: 10.2210/pdb3zoa/pdb
• Related: 3ZO9
• Related PRD ID: PRD_900007
• Descriptor: TREHALOSE SYNTHASE/AMYLASE TRES, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase, glycohydrolase, drug design, tuberculosis
• Biological source: MYCOBACTERIUM SMEGMATIS
• Total number of polymer chains: 2
• Total formula weight: 137566.81

Authors

Caner, S.,Nguyen, N.,Aguda, A.,Zhang, R.,Pan, Y.T.,Withers, S.G.,Brayer, G.D. (deposition date: 2013-02-21, release date: 2013-07-17, Last modification date: 2023-12-20)

• Primary citation: Caner, S.,Nguyen, N.,Aguda, A.,Zhang, R.,Pan, Y.T.,Withers, S.G.,Brayer, G.D.; The Structure of the Mycobacterium Smegmatis Trehalose Synthase Reveals an Unusual Active Site Configuration and Acarbose-Binding Mode.; Glycobiology, 23:1075-, 2013; PubMed: 23735230; DOI: 10.1093/GLYCOB/CWT044

Experimental method

X-RAY DIFFRACTION (1.85 Å)