6OCN

Montbretin A analogue M06-MbA in complex with Human pancreatic alpha-amylase

Summary for 6OCN

Entry DOI	10.2210/pdb6ocn/pdb
Descriptor	Pancreatic alpha-amylase, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-(3-{[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-3-yl]oxy}propyl)-1-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-L-prolinamide, ... (6 entities in total)
Functional Keywords	amylase, diabetes, obesity, glucosyl hydrolase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56846.63
Authors	Caner, S.,Brayer, G.D. (deposition date: 2019-03-25, release date: 2020-02-12, Last modification date: 2023-10-11)
Primary citation	Tysoe, C.R.,Caner, S.,Calvert, M.B.,Win-Mason, A.,Brayer, G.D.,Withers, S.G. Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase. Chem Sci, 10:11073-11077, 2019 Cited by PubMed: 32206255 DOI: 10.1039/c9sc02610j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.147 Å)

Structure validation