5KEZ
Selective and potent inhibition of the glycosidase human amylase by the short and extremely compact peptide piHA from mRNA display
Summary for 5KEZ
Entry DOI | 10.2210/pdb5kez/pdb |
Related | 1CPU 4W93 4X9Y |
Descriptor | Pancreatic alpha-amylase, ACE-DTY-PRO-TYR-SER-CYS-TRP-VAL-ARG-HIS-NH2, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | amylase, diabetes, obesity, glucosyl hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted, extracellular space: P04746 |
Total number of polymer chains | 2 |
Total formula weight | 57243.26 |
Authors | Caner, S.,Brayer, G.D. (deposition date: 2016-06-10, release date: 2017-03-29, Last modification date: 2023-09-27) |
Primary citation | Jongkees, S.A.,Caner, S.,Tysoe, C.,Brayer, G.D.,Withers, S.G.,Suga, H. Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides. Cell Chem Biol, 24:381-390, 2017 Cited by PubMed: 28262556DOI: 10.1016/j.chembiol.2017.02.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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