5KEZ

Selective and potent inhibition of the glycosidase human amylase by the short and extremely compact peptide piHA from mRNA display

Summary for 5KEZ

• Entry DOI: 10.2210/pdb5kez/pdb
• Related: 1CPU 4W93 4X9Y
• Descriptor: Pancreatic alpha-amylase, ACE-DTY-PRO-TYR-SER-CYS-TRP-VAL-ARG-HIS-NH2, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: amylase, diabetes, obesity, glucosyl hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted, extracellular space: P04746
• Total number of polymer chains: 2
• Total formula weight: 57243.26

Authors

Caner, S.,Brayer, G.D. (deposition date: 2016-06-10, release date: 2017-03-29, Last modification date: 2023-09-27)

• Primary citation: Jongkees, S.A.,Caner, S.,Tysoe, C.,Brayer, G.D.,Withers, S.G.,Suga, H.; Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.; Cell Chem Biol, 24:381-390, 2017; PubMed: 28262556; DOI: 10.1016/j.chembiol.2017.02.001

Experimental method

X-RAY DIFFRACTION (1.83 Å)