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6OBX

Montbretin A analogue M10-MbA in complex with Human pancreatic alpha-amylase

Summary for 6OBX
Entry DOI10.2210/pdb6obx/pdb
DescriptorPancreatic alpha-amylase, CHLORIDE ION, CALCIUM ION, ... (7 entities in total)
Functional Keywordsamylase, diabetes, obesity, glucosyl hydrolase, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight57030.86
Authors
Caner, S.,Brayer, G.D. (deposition date: 2019-03-21, release date: 2020-02-12, Last modification date: 2023-10-11)
Primary citationTysoe, C.R.,Caner, S.,Calvert, M.B.,Win-Mason, A.,Brayer, G.D.,Withers, S.G.
Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase.
Chem Sci, 10:11073-11077, 2019
Cited by
PubMed: 32206255
DOI: 10.1039/c9sc02610j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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