4X0N

Porcine pancreatic alpha-amylase in complex with helianthamide, a novel proteinaceous inhibitor

Summary for 4X0N

• Entry DOI: 10.2210/pdb4x0n/pdb
• Descriptor: Pancreatic alpha-amylase, Helianthamide, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: amylase, inhibitor, diabetes, protein inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 2
• Total formula weight: 60236.67

Authors

Williams, L.K.,Brayer, G.D. (deposition date: 2014-11-21, release date: 2015-11-25, Last modification date: 2023-09-27)

• Primary citation: Tysoe, C.,Williams, L.K.,Keyzers, R.,Nguyen, N.T.,Aguda, A.,Zhang, X.,Tarling, C.A.,Andersen, R.J.,Brayer, G.D.,Withers, S.G.; Structural Templating and Guided Refolding of the Potent Naturally Occurring Peptide Helianthamide Within the Active Site of Amylase, a Diabetes and Obesity Therapeutic Target; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6001 Å)