4X0N
Porcine pancreatic alpha-amylase in complex with helianthamide, a novel proteinaceous inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Pancreatic alpha-amylase | polymer | 496 | 55373.7 | 1 | UniProt (P00690) Pfam (PF00128) Pfam (PF02806) | Sus scrofa (Pig) | PA,1,4-alpha-D-glucan glucanohydrolase |
| 2 | B (B) | Helianthamide | polymer | 44 | 4695.4 | 1 | UniProt (by SIFTS) (A0A0X1KGZ5) | Stichodactyla helianthus | |
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A: 1 - 496 (UniProt: P00690)
| PDB | External Database | Details |
|---|---|---|
| Val 49 | Ile 64 | conflict |
| Ser 123 | Asn 138 | conflict |
| Ser 243 | Gln 258 | conflict |
| Ser 310 | Ala 325 | conflict |
| Glu 352 | Gln 367 | conflict |
| Glu 390 | Gln 405 | conflict |
| Asp 411 | Ala 426 | conflict |
| Asn 451 | Asp 466 | conflict |
| Gln 484 | Glu 499 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60069.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 167.6 | |
| All* | Total formula weight | 60236.7 |
