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PDB: 42 件
7JHY
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BU of 7jhy by Molmil
Type IV-B CRISPR Complex
分子名称: Csf2 (Cas7), Csf4 (Cas11), RNA (31-MER)
著者Bravo, J.P.K, Taylor, D.W.
登録日2020-07-21
公開日2021-03-31
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structure of a type IV CRISPR-Cas ribonucleoprotein complex.
Iscience, 24, 2021
7PKO
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BU of 7pko by Molmil
CryoEM structure of Rotavirus NSP2
分子名称: Non-structural protein 2
著者Bravo, J.P.K, Borodavka, A.
登録日2021-08-26
公開日2021-09-29
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structural basis of rotavirus RNA chaperone displacement and RNA annealing.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PKP
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NSP2 RNP complex
分子名称: Non-structural protein 2
著者Bravo, J.P.K, Borodavka, A.
登録日2021-08-26
公開日2021-09-29
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of rotavirus RNA chaperone displacement and RNA annealing.
Proc.Natl.Acad.Sci.USA, 118, 2021
4D7Z
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BU of 4d7z by Molmil
E. coli L-aspartate-alpha-decarboxylase mutant N72Q to a resolution of 1.9 Angstroms
分子名称: ASPARTATE 1-DECARBOXYLASE ALPHA CHAIN, ASPARTATE 1-DECARBOXYLASE BETA CHAIN, DI(HYDROXYETHYL)ETHER, ...
著者Bravo, J.P.K, Monteiro, D.C.F, Webb, M.E, Pearson, A.R.
登録日2014-12-02
公開日2016-01-13
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Structure of the E. Coli L-Aspartate-Alpha-Decarboxylase Mutant N72Q to a Resolution of 1.9 Angstroms
To be Published
7L1F
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BU of 7l1f by Molmil
SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate
分子名称: Non-structural protein 7, Non-structural protein 8, RNA (5'-R(P*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*G)-3'), ...
著者Bravo, J.P.K, Taylor, D.W.
登録日2020-12-14
公開日2021-02-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication.
Mol.Cell, 81, 2021
7S9V
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BU of 7s9v by Molmil
DrmAB:ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, DrmA, DrmB
著者Bravo, J.P.K, Taylor, D.W, Brouns, S.J.J, Aparicio-Maldonado, C.
登録日2021-09-21
公開日2022-06-15
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for broad anti-phage immunity by DISARM.
Nat Commun, 13, 2022
7S9W
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BU of 7s9w by Molmil
Structure of DrmAB:ADP:DNA complex
分子名称: ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DrmA, ...
著者Bravo, J.P.K, Taylor, D.W, Brounds, S.J.J, Aparicio-Maldonado, C.
登録日2021-09-21
公開日2022-06-15
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis for broad anti-phage immunity by DISARM.
Nat Commun, 13, 2022
7S4U
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Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand, Target strand, ...
著者Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A.
登録日2021-09-09
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
7S4V
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Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation
分子名称: CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ...
著者Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A.
登録日2021-09-09
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
7S4X
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Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ...
著者Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A.
登録日2021-09-09
公開日2022-03-02
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structural basis for mismatch surveillance by CRISPR-Cas9.
Nature, 603, 2022
8D49
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Structure of Cas12a2 binary complex
分子名称: OrfB_Zn_ribbon domain-containing protein, RNA (26-MER)
著者Bravo, J.P.K, Taylor, D.W.
登録日2022-06-01
公開日2023-01-18
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Nature, 613, 2023
8D4A
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Cas12a2 quaternary complex
分子名称: DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ...
著者Bravo, J.P.K, Taylor, D.W.
登録日2022-06-01
公開日2023-01-18
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Nature, 613, 2023
8D4B
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Structure of Cas12a2 ternary complex
分子名称: OrfB_Zn_ribbon domain-containing protein, RNA (28-MER), RNA (41-MER)
著者Bravo, J.P.K, Taylor, D.W.
登録日2022-06-01
公開日2023-01-18
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Nature, 613, 2023
8TL0
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BU of 8tl0 by Molmil
Structure of activated SAVED-CHAT filament
分子名称: CHAT domain-containing protein, RNA (5'-R(*AP*AP*A)-3')
著者Bravo, J.P.K, Taylor, D.W.
登録日2023-07-26
公開日2024-03-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Type III-B CRISPR-Cas cascade of proteolytic cleavages.
Science, 383, 2024
8TZZ
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BU of 8tzz by Molmil
SpG Cas9 with NGC PAM DNA target
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*GP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Bravo, J.P.K, Hibshman, G.N, Taylor, D.W.
登録日2023-08-28
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.56 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8U3Y
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SpG Cas9 with NGG PAM DNA target
分子名称: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ...
著者Bravo, J.P.K, Hibshman, G.N, Taylor, D.W.
登録日2023-09-08
公開日2024-05-01
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9.
Nat Commun, 15, 2024
8U0J
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DdmE in complex with guide and target DNA
分子名称: DNA (5'-D(P*AP*CP*TP*TP*AP*AP*AP*GP*TP*CP*TP*AP*AP*CP*CP*TP*AP*TP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*AP*TP*AP*GP*GP*A)-3'), DNA (5'-D(P*GP*TP*TP*AP*GP*AP*CP*TP*TP*TP*AP*AP*GP*T)-3'), ...
著者Bravo, J.P.K.
登録日2023-08-29
公開日2024-07-03
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U0W
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DdmD monomer in complex with ssDNA
分子名称: DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein
著者Bravo, J.P.K.
登録日2023-08-29
公開日2024-07-10
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U0U
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DdmD dimer in complex with ssDNA
分子名称: DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein
著者Bravo, J.P.K.
登録日2023-08-29
公開日2024-07-10
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
8U3K
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DdmDE handover complex
分子名称: DNA (29-MER), DNA (5'-D(P*GP*GP*AP*AP*AP*TP*GP*TP*TP*GP*AP*AP*TP*AP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ...
著者Bravo, J.P.K.
登録日2023-09-07
公開日2024-07-10
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
9BQV
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DdmD dimer apoprotein
分子名称: Helicase/UvrB N-terminal domain-containing protein
著者Bravo, J.P.K, Taylor, D.W.
登録日2024-05-10
公開日2024-07-03
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Plasmid targeting and destruction by the DdmDE bacterial defence system.
Nature, 630, 2024
7UG6
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Cryo-EM structure of pre-60S ribosomal subunit, unmethylated G2922
分子名称: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Yelland, J.N, Bravo, J.P.K, Black, J.J.B, Taylor, D.W, Johnson, A.W.
登録日2022-03-24
公開日2022-12-21
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献A single 2'-O-methylation of ribosomal RNA gates assembly of a functional ribosome.
Nat.Struct.Mol.Biol., 30, 2023
7KHA
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Cryo-EM Structure of the Desulfovibrio vulgaris Type I-C Apo Cascade
分子名称: CRISPR-associated protein, CT1133 family, CT1134 family, ...
著者O'Brien, R, Wrapp, D, Bravo, J.P.K, Schwartz, E, Taylor, D.
登録日2020-10-20
公開日2020-11-11
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.13 Å)
主引用文献Structural basis for assembly of non-canonical small subunits into type I-C Cascade.
Nat Commun, 11, 2020
8DFS
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type I-C Cascade bound to AcrIF2
分子名称: Anti-CRISPR protein 30, CRISPR-associated protein, CT1133 family, ...
著者O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W.
登録日2022-06-22
公開日2023-02-22
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.
Mol.Cell, 83, 2023
8DFO
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type I-C Cascade bound to AcrIC4
分子名称: AcrIC4, CRISPR-associated protein, CT1133 family, ...
著者O'Brien, R.E, Bravo, J.P.K, Ramos, D, Hibshman, G.N, Wright, J.T, Taylor, D.W.
登録日2022-06-22
公開日2023-02-15
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural snapshots of R-loop formation by a type I-C CRISPR Cascade.
Mol.Cell, 83, 2023

 

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