8D4A

Cas12a2 quaternary complex

Summary for 8D4A

Entry DOI	10.2210/pdb8d4a/pdb
EMDB information	27179
Descriptor	OrfB_Zn_ribbon domain-containing protein, RNA (41-MER), RNA (28-MER), ... (8 entities in total)
Functional Keywords	cas12a2, crispr, nuclease, dna binding protein-rna-dna complex, dna binding protein/rna/dna
Biological source	Sulfuricurvum sp. PC08-66 More
Total number of polymer chains	5
Total formula weight	172074.41
Authors	Bravo, J.P.K.,Taylor, D.W. (deposition date: 2022-06-01, release date: 2023-01-18, Last modification date: 2023-02-01)
Primary citation	Bravo, J.P.K.,Hallmark, T.,Naegle, B.,Beisel, C.L.,Jackson, R.N.,Taylor, D.W. RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2. Nature, 613:582-587, 2023 Cited by PubMed: 36599980 DOI: 10.1038/s41586-022-05560-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.74 Å)

Structure validation