1IPH
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![BU of 1iph by Molmil](/molmil-images/mine/1iph) | |
7JHY
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![BU of 7jhy by Molmil](/molmil-images/mine/7jhy) | Type IV-B CRISPR Complex | Descriptor: | Csf2 (Cas7), Csf4 (Cas11), RNA (31-MER) | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2020-07-21 | Release date: | 2021-03-31 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of a type IV CRISPR-Cas ribonucleoprotein complex. Iscience, 24, 2021
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2YDL
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![BU of 2ydl by Molmil](/molmil-images/mine/2ydl) | Crystal structure of SH3C from CIN85 | Descriptor: | SH3 DOMAIN-CONTAINING KINASE-BINDING PROTEIN 1 | Authors: | Bravo, J, Cardenes, N. | Deposit date: | 2011-03-22 | Release date: | 2012-03-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications. Plos One, 8, 2013
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7S9W
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![BU of 7s9w by Molmil](/molmil-images/mine/7s9w) | Structure of DrmAB:ADP:DNA complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DrmA, ... | Authors: | Bravo, J.P.K, Taylor, D.W, Brounds, S.J.J, Aparicio-Maldonado, C. | Deposit date: | 2021-09-21 | Release date: | 2022-06-15 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for broad anti-phage immunity by DISARM. Nat Commun, 13, 2022
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7S9V
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![BU of 7s9v by Molmil](/molmil-images/mine/7s9v) | DrmAB:ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DrmA, DrmB | Authors: | Bravo, J.P.K, Taylor, D.W, Brouns, S.J.J, Aparicio-Maldonado, C. | Deposit date: | 2021-09-21 | Release date: | 2022-06-15 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for broad anti-phage immunity by DISARM. Nat Commun, 13, 2022
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7PKO
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![BU of 7pko by Molmil](/molmil-images/mine/7pko) | CryoEM structure of Rotavirus NSP2 | Descriptor: | Non-structural protein 2 | Authors: | Bravo, J.P.K, Borodavka, A. | Deposit date: | 2021-08-26 | Release date: | 2021-09-29 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PKP
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![BU of 7pkp by Molmil](/molmil-images/mine/7pkp) | NSP2 RNP complex | Descriptor: | Non-structural protein 2 | Authors: | Bravo, J.P.K, Borodavka, A. | Deposit date: | 2021-08-26 | Release date: | 2021-09-29 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of rotavirus RNA chaperone displacement and RNA annealing. Proc.Natl.Acad.Sci.USA, 118, 2021
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7S4X
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![BU of 7s4x by Molmil](/molmil-images/mine/7s4x) | Cas9:gRNA in complex with 18-20MM DNA, 1 minute time-point, kinked active conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, NTS, ... | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | Deposit date: | 2021-09-09 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9. Nature, 603, 2022
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7S4V
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![BU of 7s4v by Molmil](/molmil-images/mine/7s4v) | Cas9 bound to 12-14MM DNA, 60 min time-point, kinked conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, NTS, TS, ... | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | Deposit date: | 2021-09-09 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9. Nature, 603, 2022
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7S4U
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![BU of 7s4u by Molmil](/molmil-images/mine/7s4u) | Cryo-EM structure of Cas9 in complex with 12-14MM DNA substrate, 5 minute time-point | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target strand, Target strand, ... | Authors: | Bravo, J.P.K, Taylor, D.W, Liu, M.S, Johnson, K.A. | Deposit date: | 2021-09-09 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Structural basis for mismatch surveillance by CRISPR-Cas9. Nature, 603, 2022
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1BQU
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![BU of 1bqu by Molmil](/molmil-images/mine/1bqu) | CYTOKYNE-BINDING REGION OF GP130 | Descriptor: | GLYCEROL, PROTEIN (GP130), SULFATE ION | Authors: | Bravo, J, Staunton, D, Heath, J.K, Jones, E.Y. | Deposit date: | 1998-08-18 | Release date: | 1998-08-26 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a cytokine-binding region of gp130. EMBO J., 17, 1998
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7L1F
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![BU of 7l1f by Molmil](/molmil-images/mine/7l1f) | SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate | Descriptor: | Non-structural protein 7, Non-structural protein 8, RNA (5'-R(P*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*G)-3'), ... | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2020-12-14 | Release date: | 2021-02-10 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication. Mol.Cell, 81, 2021
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4D7Z
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![BU of 4d7z by Molmil](/molmil-images/mine/4d7z) | E. coli L-aspartate-alpha-decarboxylase mutant N72Q to a resolution of 1.9 Angstroms | Descriptor: | ASPARTATE 1-DECARBOXYLASE ALPHA CHAIN, ASPARTATE 1-DECARBOXYLASE BETA CHAIN, DI(HYDROXYETHYL)ETHER, ... | Authors: | Bravo, J.P.K, Monteiro, D.C.F, Webb, M.E, Pearson, A.R. | Deposit date: | 2014-12-02 | Release date: | 2016-01-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The Structure of the E. Coli L-Aspartate-Alpha-Decarboxylase Mutant N72Q to a Resolution of 1.9 Angstroms To be Published
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8TL0
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![BU of 8tl0 by Molmil](/molmil-images/mine/8tl0) | |
8U3Y
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![BU of 8u3y by Molmil](/molmil-images/mine/8u3y) | SpG Cas9 with NGG PAM DNA target | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*CP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... | Authors: | Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. | Deposit date: | 2023-09-08 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nat Commun, 15, 2024
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8TZZ
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![BU of 8tzz by Molmil](/molmil-images/mine/8tzz) | SpG Cas9 with NGC PAM DNA target | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(P*CP*GP*TP*TP*TP*GP*TP*AP*CP*TP*GP*CP*AP*GP*CP*G)-3'), DNA (5'-D(P*TP*CP*TP*CP*AP*TP*CP*TP*TP*TP*AP*TP*GP*CP*GP*TP*C)-3'), ... | Authors: | Bravo, J.P.K, Hibshman, G.N, Taylor, D.W. | Deposit date: | 2023-08-28 | Release date: | 2024-05-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.56 Å) | Cite: | Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9. Nat Commun, 15, 2024
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1H9D
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![BU of 1h9d by Molmil](/molmil-images/mine/1h9d) | Aml1/cbf-beta/dna complex | Descriptor: | CORE-BINDING FACTOR ALPHA SUBUNIT1, CORE-BINDING FACTOR CBF-BETA, DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3'), ... | Authors: | Bravo, J, Warren, A.J. | Deposit date: | 2001-03-07 | Release date: | 2001-03-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp Nat.Struct.Biol., 8, 2001
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8U0J
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![BU of 8u0j by Molmil](/molmil-images/mine/8u0j) | DdmE in complex with guide and target DNA | Descriptor: | DNA (5'-D(P*AP*CP*TP*TP*AP*AP*AP*GP*TP*CP*TP*AP*AP*CP*CP*TP*AP*TP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*AP*TP*AP*GP*GP*A)-3'), DNA (5'-D(P*GP*TP*TP*AP*GP*AP*CP*TP*TP*TP*AP*AP*GP*T)-3'), ... | Authors: | Bravo, J.P.K. | Deposit date: | 2023-08-29 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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8U3K
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![BU of 8u3k by Molmil](/molmil-images/mine/8u3k) | DdmDE handover complex | Descriptor: | DNA (29-MER), DNA (5'-D(P*GP*GP*AP*AP*AP*TP*GP*TP*TP*GP*AP*AP*TP*AP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Bravo, J.P.K. | Deposit date: | 2023-09-07 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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8U0U
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![BU of 8u0u by Molmil](/molmil-images/mine/8u0u) | DdmD dimer in complex with ssDNA | Descriptor: | DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein | Authors: | Bravo, J.P.K. | Deposit date: | 2023-08-29 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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8U0W
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![BU of 8u0w by Molmil](/molmil-images/mine/8u0w) | DdmD monomer in complex with ssDNA | Descriptor: | DNA (5'-D(P*TP*TP*AP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Helicase/UvrB N-terminal domain-containing protein | Authors: | Bravo, J.P.K. | Deposit date: | 2023-08-29 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.99 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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9BQV
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![BU of 9bqv by Molmil](/molmil-images/mine/9bqv) | DdmD dimer apoprotein | Descriptor: | Helicase/UvrB N-terminal domain-containing protein | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2024-05-10 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Plasmid targeting and destruction by the DdmDE bacterial defence system. Nature, 630, 2024
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8D49
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![BU of 8d49 by Molmil](/molmil-images/mine/8d49) | Structure of Cas12a2 binary complex | Descriptor: | OrfB_Zn_ribbon domain-containing protein, RNA (26-MER) | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2022-06-01 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2. Nature, 613, 2023
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8D4A
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![BU of 8d4a by Molmil](/molmil-images/mine/8d4a) | Cas12a2 quaternary complex | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, ... | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2022-06-01 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2. Nature, 613, 2023
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8D4B
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![BU of 8d4b by Molmil](/molmil-images/mine/8d4b) | Structure of Cas12a2 ternary complex | Descriptor: | OrfB_Zn_ribbon domain-containing protein, RNA (28-MER), RNA (41-MER) | Authors: | Bravo, J.P.K, Taylor, D.W. | Deposit date: | 2022-06-01 | Release date: | 2023-01-18 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2. Nature, 613, 2023
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