6HM8
 
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6HLN
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6HLT
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6HLV
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6HMV
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8A23
 | | Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in complex with TO383 | | Descriptor: | (2R,3R,4S,5R)-2-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol, 2'-O-methyltransferase nsp16, GLYCEROL, ... | | Authors: | Hanigovsky, M, Krafcikova, P, Klima, M, Boura, E. | | Deposit date: | 2022-06-02 | | Release date: | 2023-06-14 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of SARS-CoV-2 nsp10/nsp16 methyltransferase in
complex with TO383
To Be Published
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7ZKU
 | | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP) | | Descriptor: | 9-[(1~{S},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]-2-azanyl-3~{H}-purin-6-one, Stimulator of interferon protein | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-04-13 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'dGMP)
To Be Published
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7ZVK
 | | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-IMP) | | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9-fluoranyl-3,12,18-tris(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]-3~{H}-purin-6-one, Stimulator of interferon protein | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-05-16 | | Release date: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-IMP)
To Be Published
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7ZWL
 | | Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP) | | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine, Stimulator of interferon protein, Ubiquitin-like protein SMT3 | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-05-19 | | Release date: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP)
To Be Published
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7ZXB
 | | Crystal structure of human STING in complex with 3',3'-c-(2'dAMP-2'F,2'dAMP) | | Descriptor: | 9-[(1~{R},6~{R},8~{R},10~{S},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-18-fluoranyl-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-05-20 | | Release date: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'dAMP-2'F,2'dAMP)
To Be Published
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7ZV0
 | | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP) | | Descriptor: | 9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-05-13 | | Release date: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP)
To Be Published
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8A2X
 | | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP(S)-2'F,2'dAMP(S)) | | Descriptor: | 9-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein | | Authors: | Klima, M, Smola, M, Boura, E. | | Deposit date: | 2022-06-06 | | Release date: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP(S)-2'F,2'dAMP(S))
To Be Published
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6Q69
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6Q67
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8B07
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6Q68
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8A5X
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7ZIT
 | | 14-3-3 in complex with SARS-COV2 N phospho-peptide | | Descriptor: | 14-3-3 protein zeta/delta, ACETATE ION, BENZOIC ACID, ... | | Authors: | Eisenreichova, A, Boura, E. | | Deposit date: | 2022-04-08 | | Release date: | 2022-10-26 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structural basis for SARS-CoV-2 nucleocapsid (N) protein recognition by 14-3-3 proteins.
J.Struct.Biol., 214, 2022
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6R1I
 | | Structure of porcine Aichi virus polymerase | | Descriptor: | Genome polyprotein | | Authors: | Dubankova, A, Boura, E. | | Deposit date: | 2019-03-14 | | Release date: | 2019-10-09 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.634 Å) | | Cite: | Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation.
J.Struct.Biol., 208, 2019
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6QWT
 | | Sicinivirus 3Dpol RNA dependent RNA polymerase | | Descriptor: | Genome polyprotein | | Authors: | Dubankova, A, Boura, E. | | Deposit date: | 2019-03-06 | | Release date: | 2019-10-09 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structures of kobuviral and siciniviral polymerases reveal conserved mechanism of picornaviral polymerase activation.
J.Struct.Biol., 208, 2019
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6S27
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6YZ1
 | | The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SINEFUNGIN, ZINC ION, ... | | Authors: | Krafcikova, P, Silhan, J, Nencka, R, Boura, E. | | Deposit date: | 2020-05-06 | | Release date: | 2020-05-13 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin.
Nat Commun, 11, 2020
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8A2H
 | | human STING in complex with 2',3'-cyclic-GMP-7-deazaphenyl-AMP | | Descriptor: | 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-(4-azanyl-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein | | Authors: | Smola, M, Vavrina, Z, Boura, E, Brynda, J. | | Deposit date: | 2022-06-03 | | Release date: | 2022-10-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
J.Med.Chem., 65, 2022
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6TC6
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6TC9
 | | Crystal structure of MutM from Neisseria meningitidis | | Descriptor: | DNA, DNA containing abasic site analogue, Formamidopyrimidine-DNA glycosylase, ... | | Authors: | Silhan, J, Landova, B, Boura, E. | | Deposit date: | 2019-11-05 | | Release date: | 2020-09-16 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.175 Å) | | Cite: | Conformational changes of DNA repair glycosylase MutM triggered by DNA binding.
Febs Lett., 594, 2020
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