1DNC
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![BU of 1dnc by Molmil](/molmil-images/mine/1dnc) | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DIGLUTATHIONE-DINITROSO-IRON | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | Deposit date: | 1998-02-20 | Release date: | 1998-05-27 | Last modified: | 2011-12-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Nat.Struct.Biol., 5, 1998
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1GSN
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![BU of 1gsn by Molmil](/molmil-images/mine/1gsn) | HUMAN GLUTATHIONE REDUCTASE MODIFIED BY DINITROSOGLUTATHIONE | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONE, GLUTATHIONE REDUCTASE, ... | Authors: | Becker, K, Savvides, S.N, Keese, M, Schirmer, R.H, Karplus, P.A. | Deposit date: | 1998-02-21 | Release date: | 1998-05-27 | Last modified: | 2011-12-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers. Nat.Struct.Biol., 5, 1998
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3LG0
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![BU of 3lg0 by Molmil](/molmil-images/mine/3lg0) | |
7Z4M
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![BU of 7z4m by Molmil](/molmil-images/mine/7z4m) | Plasmodium falciparum pyruvate kinase complexed with Mg2+ and K+ | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | Deposit date: | 2022-03-04 | Release date: | 2022-08-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity. Structure, 30, 2022
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7Z4R
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![BU of 7z4r by Molmil](/molmil-images/mine/7z4r) | Plasmodium falciparum pyruvate kinase mutant - C343A | Descriptor: | MAGNESIUM ION, POTASSIUM ION, Pyruvate kinase | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | Deposit date: | 2022-03-04 | Release date: | 2022-08-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity. Structure, 30, 2022
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7Z4N
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![BU of 7z4n by Molmil](/molmil-images/mine/7z4n) | Plasmodium falciparum pyruvate kinase complexed with pyruvate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | Deposit date: | 2022-03-04 | Release date: | 2022-08-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity. Structure, 30, 2022
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7Z4Q
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![BU of 7z4q by Molmil](/molmil-images/mine/7z4q) | Plasmodium falciparum pyruvate kinase mutant - C49A | Descriptor: | MAGNESIUM ION, Pyruvate kinase | Authors: | Dillenberger, M, Rahlfs, S, Becker, K, Fritz-Wolf, K. | Deposit date: | 2022-03-04 | Release date: | 2022-08-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity. Structure, 30, 2022
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3NTJ
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![BU of 3ntj by Molmil](/molmil-images/mine/3ntj) | Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase | Descriptor: | Ornithine aminotransferase, SULFATE ION | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Becker, K. | Deposit date: | 2010-07-05 | Release date: | 2010-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Redox regulation of Plasmodium falciparum ornithine delta-aminotransferase J.Mol.Biol., 402, 2010
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1OKT
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![BU of 1okt by Molmil](/molmil-images/mine/1okt) | X-ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium falciparum | Descriptor: | FORMIC ACID, GLUTATHIONE S-TRANSFERASE | Authors: | Fritz-Wolf, K, Becker, A, Rahlfs, s, Harwaldt, P, Schirmer, R.H, Kabsch, W, Becker, K. | Deposit date: | 2003-07-29 | Release date: | 2003-11-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-Ray Structure of Glutathione S-Transferase from the Malarial Parasite Plasmodium Falciparum Proc.Natl.Acad.Sci.USA, 100, 2003
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8C79
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![BU of 8c79 by Molmil](/molmil-images/mine/8c79) | Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH | Descriptor: | 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Fritz-Wolf, K, Berneburg, I, Rahlfs, S, Becker, K. | Deposit date: | 2023-01-13 | Release date: | 2023-05-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment. Int J Mol Sci, 24, 2023
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7PCZ
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![BU of 7pcz by Molmil](/molmil-images/mine/7pcz) | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | Descriptor: | ETHANOL, GLYCEROL, Green fluorescent protein | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | Deposit date: | 2021-08-04 | Release date: | 2022-02-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant. Antioxid.Redox Signal., 37, 2022
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7PD0
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![BU of 7pd0 by Molmil](/molmil-images/mine/7pd0) | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Green fluorescent protein, ... | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | Deposit date: | 2021-08-04 | Release date: | 2022-02-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant. Antioxid.Redox Signal., 37, 2022
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5LLT
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![BU of 5llt by Molmil](/molmil-images/mine/5llt) | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with NaAD | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NICOTINIC ACID ADENINE DINUCLEOTIDE, ... | Authors: | Bathke, J, Fritz-Wolf, K, Brandstaedter, C, Rahlfs, S, Becker, K. | Deposit date: | 2016-07-28 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase. J. Mol. Biol., 428, 2016
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5LM3
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![BU of 5lm3 by Molmil](/molmil-images/mine/5lm3) | Plasmodium falciparum nicotinic acid mononucleotide adenylyltransferase complexed with APC | Descriptor: | 1,2-ETHANEDIOL, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Nicotinate-nucleotide adenylyltransferase | Authors: | Bathke, J, Fritz-Wolf, K, Rahlfs, S, Brandstaether, C, Burkhardt, A, Becker, K. | Deposit date: | 2016-07-29 | Release date: | 2016-11-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase. J. Mol. Biol., 428, 2016
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7PCA
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![BU of 7pca by Molmil](/molmil-images/mine/7pca) | Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants | Descriptor: | ETHANOL, FORMAMIDE, GLYCEROL, ... | Authors: | Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K. | Deposit date: | 2021-08-03 | Release date: | 2022-02-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant. Antioxid.Redox Signal., 37, 2022
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6FQY
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![BU of 6fqy by Molmil](/molmil-images/mine/6fqy) | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | Descriptor: | 1,2-ETHANEDIOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | Deposit date: | 2018-02-15 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target. J. Mol. Biol., 430, 2018
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6FQX
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![BU of 6fqx by Molmil](/molmil-images/mine/6fqx) | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | Descriptor: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-phosphogluconate dehydrogenase, decarboxylating, ... | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | Deposit date: | 2018-02-15 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target. J. Mol. Biol., 430, 2018
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6FQZ
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![BU of 6fqz by Molmil](/molmil-images/mine/6fqz) | Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate | Descriptor: | 6-PHOSPHOGLUCONIC ACID, 6-phosphogluconate dehydrogenase, decarboxylating, ... | Authors: | Fritz-Wolf, K, Haeussler, K, Reichmann, M, Rahlfs, S, Becker, K. | Deposit date: | 2018-02-15 | Release date: | 2018-08-22 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target. J. Mol. Biol., 430, 2018
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4J57
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![BU of 4j57 by Molmil](/molmil-images/mine/4j57) | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Thioredoxin, ... | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | Deposit date: | 2013-02-08 | Release date: | 2013-07-10 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex. J.Mol.Biol., 425, 2013
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4J56
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![BU of 4j56 by Molmil](/molmil-images/mine/4j56) | Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Thioredoxin, Thioredoxin reductase 2 | Authors: | Fritz-Wolf, K, Jortzik, E, Stumpf, M, Preuss, J, Iozef, R, Rahlfs, S, Becker, K. | Deposit date: | 2013-02-08 | Release date: | 2013-07-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.371 Å) | Cite: | Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase-Thioredoxin Complex. J.Mol.Biol., 425, 2013
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1ALG
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![BU of 1alg by Molmil](/molmil-images/mine/1alg) | SOLUTION STRUCTURE OF AN HGR INHIBITOR, NMR, 10 STRUCTURES | Descriptor: | P11 | Authors: | Schott, M.K, Nordhoff, A, Becker, K, Kalbitzer, H.R, Schirmer, R.H. | Deposit date: | 1997-06-03 | Release date: | 1997-10-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Denaturation and reactivation of dimeric human glutathione reductase--an assay for folding inhibitors. Eur.J.Biochem., 245, 1997
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2AAQ
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![BU of 2aaq by Molmil](/molmil-images/mine/2aaq) | Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI | Descriptor: | 2-(2-PHENYL-3-PYRIDIN-2-YL-4,5,6,7-TETRAHYDRO-2H-ISOPHOSPHINDOL-1-YL)PYRIDINE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Urig, S, Fritz-Wolf, K, Reau, R, Herold-Mende, C, Toth, K, Davioud-Charvet, E, Becker, K. | Deposit date: | 2005-07-14 | Release date: | 2006-04-04 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases. Angew.Chem.Int.Ed.Engl., 45, 2006
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3R3J
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![BU of 3r3j by Molmil](/molmil-images/mine/3r3j) | Kinetic and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2 | Descriptor: | Glutamate dehydrogenase | Authors: | Zocher, K, Fritz-Wolf, K, Kehr, S, Rahlfs, S, Becker, K. | Deposit date: | 2011-03-16 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2. Mol.Biochem.Parasitol., 183, 2012
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7ZZI
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![BU of 7zzi by Molmil](/molmil-images/mine/7zzi) | Plasmodium falciparum hexokinase complexed with glucose and citrate | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Phosphotransferase, ... | Authors: | Fritz-Wolf, K, Dillenberger, M, Rahlfs, S, Becker, K. | Deposit date: | 2022-05-25 | Release date: | 2023-08-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium -Specific Insertion. Int J Mol Sci, 24, 2023
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1K4Q
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![BU of 1k4q by Molmil](/molmil-images/mine/1k4q) | Human Glutathione Reductase Inactivated by Peroxynitrite | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Glutathione Reductase | Authors: | Savvides, S.N, Scheiwein, M, Boehme, C.C, Arteel, G.E, Karplus, P.A, Becker, K, Schirmer, R.H. | Deposit date: | 2001-10-08 | Release date: | 2002-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of the antioxidant enzyme glutathione reductase inactivated by peroxynitrite. J.Biol.Chem., 277, 2002
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