7WAE
| Trichodesmium erythraeum cyanophycin synthetase 1 (TeCphA1) with ATPgammaS, 4x(beta-Asp-Arg), and aspartate | 分子名称: | 4x(beta-Asp-Arg), ARGININE, ASPARTIC ACID, ... | 著者 | Miyakawa, T, Yang, J, Kawasaki, M, Adachi, N, Fujii, A, Miyauchi, Y, Muramatsu, T, Moriya, T, Senda, T, Tanokura, M. | 登録日 | 2021-12-14 | 公開日 | 2022-09-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase. Nat Commun, 13, 2022
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4N47
| Structure of Thermus thermophilus Argonaute bound to guide DNA and 12-mer target DNA | 分子名称: | 5'-D(*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', Argonaute, ... | 著者 | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | 登録日 | 2013-10-08 | 公開日 | 2014-01-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.823 Å) | 主引用文献 | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
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3RC8
| Human Mitochondrial Helicase Suv3 in Complex with Short RNA Fragment | 分子名称: | ATP-dependent RNA helicase SUPV3L1, mitochondrial, RNA fragment | 著者 | Dauter, Z, Jedrzejczak, R, Dauter, M, Wang, J, Szczesny, R, Stepien, P. | 登録日 | 2011-03-30 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Human Suv3 protein reveals unique features among SF2 helicases. Acta Crystallogr.,Sect.D, 67, 2011
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4IXL
| Crystal structure of endo-beta-1,4-xylanase from the alkaliphilic Bacillus sp. SN5 | 分子名称: | SULFATE ION, xylanase | 著者 | Bai, W.Q, Xue, Y.F, Huang, J.X, Zhou, C, Guo, R.T, Ma, Y.H. | 登録日 | 2013-01-26 | 公開日 | 2014-02-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Structure Analysis of Alkaline xylanase from Alkaliphilic Bacillus sp. SN5 Implications for pH-dependent enzyme activity To be Published
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2Q8I
| Pyruvate dehydrogenase kinase isoform 3 in complex with antitumor drug radicicol | 分子名称: | DIHYDROLIPOIC ACID, Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, GLYCEROL, ... | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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3KZ9
| Crystal structure of the master transcriptional regulator, SmcR, in Vibrio vulnificus provides insight into its DNA recognition mechanism | 分子名称: | SULFATE ION, SmcR | 著者 | Kim, M.H, Kim, Y, Choi, W.-C, Hwang, J. | 登録日 | 2009-12-08 | 公開日 | 2010-03-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The crystal structure of SmcR, a quorum-sensing master regulator of Vibrio vulnificus, provides insight into its regulation of transcription J.Biol.Chem., 285, 2010
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2PQE
| Solution structure of proline-free mutant of staphylococcal nuclease | 分子名称: | Thermonuclease | 著者 | Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J. | 登録日 | 2007-05-01 | 公開日 | 2007-06-19 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease. Biochemistry, 46, 2007
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3RNM
| The crystal structure of the subunit binding of human dihydrolipoamide transacylase (E2b) bound to human dihydrolipoamide dehydrogenase (E3) | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, BETA-MERCAPTOETHANOL, Dihydrolipoyl dehydrogenase, ... | 著者 | Brautigam, C.A, Wynn, R.M, Chuang, J.C, Young, B.B, Chuang, D.T. | 登録日 | 2011-04-22 | 公開日 | 2011-05-04 | 最終更新日 | 2011-07-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain {alpha}-Ketoacid Dehydrogenase Complex. J.Biol.Chem., 286, 2011
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4KPY
| DNA binding protein and DNA complex structure | 分子名称: | DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), ... | 著者 | Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y. | 登録日 | 2013-05-14 | 公開日 | 2014-01-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | 主引用文献 | Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc.Natl.Acad.Sci.USA, 111, 2014
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3EXF
| Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | 分子名称: | MAGNESIUM ION, POTASSIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, ... | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | 登録日 | 2008-10-16 | 公開日 | 2008-11-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure, 16, 2008
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2Q8H
| Structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (DCA) | 分子名称: | DICHLORO-ACETIC ACID, POTASSIUM ION, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 | 著者 | Kato, M, Li, J, Chuang, J.L, Chuang, D.T. | 登録日 | 2007-06-10 | 公開日 | 2007-07-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol. Structure, 15, 2007
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3EXG
| Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex | 分子名称: | POTASSIUM ION, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, ... | 著者 | Kato, M, Wynn, R.M, Chuang, J.L, Tso, S.-C, Machius, M, Li, J, Chuang, D.T. | 登録日 | 2008-10-16 | 公開日 | 2008-11-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops. Structure, 16, 2008
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7XDQ
| Crystal structure of a glucosylglycerol phosphorylase mutant from Marinobacter adhaerens | 分子名称: | Glucosylglycerol phosphorylase, LITHIUM ION, beta-D-glucopyranose | 著者 | Wei, H.L, Li, Q, Yang, J.G, Liu, W.D, Sun, Y.X. | 登録日 | 2022-03-28 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Protein Engineering of Glucosylglycerol Phosphorylase Facilitating Efficient and Highly Regio- and Stereoselective Glycosylation of Polyols in a Synthetic System. Acs Catalysis, 2022
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2BAZ
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4RVZ
| Crystal structure of tRNA fluorescent labeling enzyme | 分子名称: | MAGNESIUM ION, N-(4-aminobutyl)-2-azidoacetamide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Dong, J, Li, F, Wang, J, Gong, W. | 登録日 | 2014-11-29 | 公開日 | 2015-03-11 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A covalent approach for site-specific RNA labeling in Mammalian cells. Angew.Chem.Int.Ed.Engl., 54, 2015
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3TKZ
| Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide | 分子名称: | PROTEIN (RVIpYFVPLNR peptide), Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | 登録日 | 2011-08-29 | 公開日 | 2011-10-26 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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4EO7
| Crystal structure of the TIR domain of human myeloid differentiation primary response protein 88. | 分子名称: | MAGNESIUM ION, Myeloid differentiation primary response protein MyD88 | 著者 | Snyder, G.A, Cirl, C, Jiang, J.S, Chen, P, Smith, T, Xiao, T.S. | 登録日 | 2012-04-13 | 公開日 | 2013-04-10 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc.Natl.Acad.Sci.USA, 110, 2013
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3TL0
| Structure of SHP2 N-SH2 domain in complex with RLNpYAQLWHR peptide | 分子名称: | RLNpYAQLWHR peptide, SULFATE ION, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Zhang, Y, Zhang, J, Yuan, C, Hard, R.L, Park, I.H, Li, C, Bell, C.E, Pei, D. | 登録日 | 2011-08-29 | 公開日 | 2011-09-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry, 50, 2011
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7F42
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3TZ5
| Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex with ADP | 分子名称: | 4-PHENYL-BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tso, S.C, Chuang, J.L, Gui, W.J, Wynn, R.M, Li, J, Chuang, D.T. | 登録日 | 2011-09-27 | 公開日 | 2012-10-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase. Proc.Natl.Acad.Sci.USA, 110, 2013
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4B99
| Crystal Structure of MAPK7 (ERK5) with inhibitor | 分子名称: | 11-cyclopentyl-2-[[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl-phenyl]amino]-5-methyl-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MITOGEN-ACTIVATED PROTEIN KINASE 7 | 著者 | Elkins, J.M, Wang, J, Vollmar, M, Mahajan, P, Savitsky, P, Deng, X, Gray, N.S, Pike, A.C.W, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A, Knapp, S. | 登録日 | 2012-09-03 | 公開日 | 2012-09-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor. J.Med.Chem., 56, 2013
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7F41
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7F5D
| Crystal structure of BPTF-BRD with ligand DC-BPi-03 bound | 分子名称: | 6-(1H-indol-5-yl)-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF | 著者 | Lu, T, Lu, H.B, Wang, J, Lin, H, Lu, W, Luo, C. | 登録日 | 2021-06-21 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.57150865 Å) | 主引用文献 | Discovery and Optimization of Small-Molecule Inhibitors for the BPTF Bromodomains Proteins To Be Published
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7F6M
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7F43
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