5G2N
| X-ray structure of PI3Kinase Gamma in complex with Copanlisib | 分子名称: | 2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION | 著者 | Schaefer, M, Scott, W.J, Hentemann, M.F, Rowley, R.B, Bull, C.O, Jenkins, S, Bullion, A.M, Johnson, J, Redman, A, Robbins, A.H, Esler, W, Fracasso, R.P, Garrison, T, Hamilton, M, Michels, M, Wood, J.E, Wilkie, D.P, Xiao, H, Levy, J, Liu, N, Stasik, E, Brands, M, Lefranc, J. | 登録日 | 2016-04-11 | 公開日 | 2016-04-20 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Discovery and Sar of Novel 2,3-Dihydroimidazo(1,2-C)Quinazoline Pi3K Inhibitors: Identification of Copanlisib (Bay 80-6946) Chemmedchem, 11, 2016
|
|
5HXN
| Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M and E75A mutants) from the Wild Tomato Solanum habrochaites | 分子名称: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic | 著者 | Lee, C.C, Chan, Y.T, Wang, A.H.J. | 登録日 | 2016-01-31 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
|
|
6X4B
| Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-5-fluoro-8-methyl-2-naphthonitrile (JLJ655), a Non-nucleoside Inhibitor | 分子名称: | 7-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-5-fluoro-8-methylnaphthalene-2-carbonitrile, MAGNESIUM ION, Reverse transcriptase/ribonuclease H, ... | 著者 | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2020-05-22 | 公開日 | 2020-07-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
|
|
6DV5
| |
5HXO
| Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase with D71M, E75A and H103Y Mutants | 分子名称: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic | 著者 | Lee, C.C, Chan, Y.T, Wang, A.H.J. | 登録日 | 2016-01-31 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
|
|
5HXT
| Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with IPP and DMSPP | 分子名称: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | 著者 | Lee, C.C, Chan, Y.T, Wang, A.H.J. | 登録日 | 2016-01-31 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase Acs Omega, 2, 2017
|
|
5HXQ
| Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with DMSPP | 分子名称: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | 著者 | Lee, C.C, Chan, Y.T, Wang, A.H.J. | 登録日 | 2016-01-31 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase Acs Omega, 2, 2017
|
|
6XHA
| Crystal Structure of KRAS-G12V (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | 分子名称: | CHLORIDE ION, GLYCEROL, Isoform 2B of GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
6XGV
| Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
6XHB
| Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) | 分子名称: | CHLORIDE ION, GLYCEROL, GTPase KRas, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
6EF0
| Yeast 26S proteasome bound to ubiquitinated substrate (1D* motor state) | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | 登録日 | 2018-08-15 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. Science, 362, 2018
|
|
5HXP
| Crystal Structure of Z,Z-Farnesyl Diphosphate Synthase (D71M, E75A and H103Y Mutants) Complexed with IPP | 分子名称: | (2Z,6Z)-farnesyl diphosphate synthase, chloroplastic, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... | 著者 | Lee, C.C, Chan, Y.T, Wang, A.H.J. | 登録日 | 2016-01-31 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure and Potential Head-to-Middle Condensation Function of aZ,Z-Farnesyl Diphosphate Synthase. Acs Omega, 2, 2017
|
|
6XGU
| Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF | 分子名称: | GLYCEROL, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-18 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
5DYM
| Crystal structure of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291 - CdPadR_0991 to 1.89 Angstrom resolution | 分子名称: | PadR-family transcriptional regulator | 著者 | Isom, C.E, Karr, E.A, Menon, S.K, West, A.H, Richter-Addo, G.B. | 登録日 | 2015-09-24 | 公開日 | 2016-10-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.894 Å) | 主引用文献 | Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291. Bmc Microbiol., 16, 2016
|
|
6BZN
| |
3DP4
| Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA | 分子名称: | (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 3, ZINC ION | 著者 | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | 登録日 | 2008-07-07 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
|
|
6EF1
| Yeast 26S proteasome bound to ubiquitinated substrate (5D motor state) | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | 登録日 | 2018-08-15 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.73 Å) | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. Science, 362, 2018
|
|
6XAH
| Structure of a Stable Interstrand DNA Crosslink Involving an dA Amino Group and an Abasic Site | 分子名称: | DNA (5'-D(*TP*AP*GP*AP*TP*GP*AP*AP*CP*(AAB)P*TP*AP*GP*AP*CP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*TP*CP*TP*AP*AP*GP*TP*TP*CP*AP*TP*CP*TP*A)-3') | 著者 | Kellum Jr, A.H, Qiu, D, Voehler, M.W, Martin, W.J, Gates, K.S, Stone, M.P. | 登録日 | 2020-06-04 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a Stable Interstrand DNA Cross-Link Involving a beta- N -Glycosyl Linkage Between an N 6 -dA Amino Group and an Abasic Site. Biochemistry, 60, 2021
|
|
6EF2
| Yeast 26S proteasome bound to ubiquitinated substrate (5T motor state) | 分子名称: | 26S proteasome regulatory subunit 4 homolog, 26S proteasome regulatory subunit 6A, 26S proteasome regulatory subunit 6B homolog, ... | 著者 | de la Pena, A.H, Goodall, E.A, Gates, S.N, Lander, G.C, Martin, A. | 登録日 | 2018-08-15 | 公開日 | 2018-10-17 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | 主引用文献 | Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation. Science, 362, 2018
|
|
3DP6
| Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate | 分子名称: | GLUTAMIC ACID, Glutamate receptor 2, ZINC ION | 著者 | Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E. | 登録日 | 2008-07-07 | 公開日 | 2008-11-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of the S1S2 glutamate binding domain of GLuR3. Proteins, 75, 2008
|
|
6BS9
| Stage III sporulation protein AB (SpoIIIAB) | 分子名称: | SULFATE ION, Stage III sporulation protein AB | 著者 | Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A. | 登録日 | 2017-12-01 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural characterization of SpoIIIAB sporulation-essential protein in Bacillus subtilis. J. Struct. Biol., 202, 2018
|
|
6X4A
| Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) Variant in Complex with 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile (JLJ651), a Non-nucleoside Inhibitor | 分子名称: | 5-chloro-7-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-8-methyl-2-naphthonitrile, Reverse transcriptase/ribonuclease H, SULFATE ION, ... | 著者 | Chan, A.H, Duong, V.N, Ippolito, J.A, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2020-05-22 | 公開日 | 2020-07-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.537 Å) | 主引用文献 | Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site. Protein Sci., 29, 2020
|
|
6XI7
| Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form I) | 分子名称: | CHLORIDE ION, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Chan, A.H, Tran, T.H, Dharmaiah, S, Simanshu, D.K. | 登録日 | 2020-06-19 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
|
|
6BZA
| Crystal structure of halogenase PltM in complex with phloroglucinol and FAD | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Halogenase PltM, ... | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2017-12-22 | 公開日 | 2019-03-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun, 10, 2019
|
|
6BZT
| Crystal structure of halogenase PltM L111Y mutant in complex with FAD | 分子名称: | BROMIDE ION, CALCIUM ION, CHLORIDE ION, ... | 著者 | Pang, A.H, Garneau-Tsodikova, S, Tsodikov, O.V. | 登録日 | 2017-12-26 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun, 10, 2019
|
|