8D30
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![BU of 8d30 by Molmil](/molmil-images/mine/8d30) | Crystal structure of the human COPB2 WD-domains | Descriptor: | 1,2-ETHANEDIOL, Coatomer subunit beta' | Authors: | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | Deposit date: | 2022-05-31 | Release date: | 2022-11-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the human COPB2 WD-domains To Be Published
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6PY3
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6ZOY
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![BU of 6zoy by Molmil](/molmil-images/mine/6zoy) | Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
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7PC7
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![BU of 7pc7 by Molmil](/molmil-images/mine/7pc7) | The PDZ domain of SNTG1 complexed with the acetylated PDZ-binding motif of PTEN | Descriptor: | CALCIUM ION, GLYCEROL, Gamma-1-syntrophin,Annexin A2, ... | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | Deposit date: | 2021-08-03 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallogr D Struct Biol, 78, 2022
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6VSD
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6VSG
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![BU of 6vsg by Molmil](/molmil-images/mine/6vsg) | Mycobacterium tuberculosis dihydrofolate reductase in complex with 4-(trifluoromethyl)benzene-1,2-diamine(fragment 17) | Descriptor: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, COBALT (II) ION, Dihydrofolate reductase, ... | Authors: | Ribeiro, J.A, Dias, M.V.B. | Deposit date: | 2020-02-11 | Release date: | 2020-07-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.304 Å) | Cite: | Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6, 2020
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7PC3
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![BU of 7pc3 by Molmil](/molmil-images/mine/7pc3) | The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1 | Descriptor: | CALCIUM ION, Disks large homolog 1,Annexin A2, GLYCEROL, ... | Authors: | Cousido-Siah, A, Trave, G, Gogl, G. | Deposit date: | 2021-08-03 | Release date: | 2022-04-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A scalable strategy to solve structures of PDZ domains and their complexes. Acta Crystallogr D Struct Biol, 78, 2022
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6NIQ
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![BU of 6niq by Molmil](/molmil-images/mine/6niq) | Crystal Structure of the Putative Class A Beta-Lactamase PenP from Rhodopseudomonas palustris | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | Authors: | Kim, Y, Tesar, C, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2018-12-31 | Release date: | 2019-01-16 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.353 Å) | Cite: | Crystal Structure of the Putative Class A Beta-Lactamase PenP from Rhodopseudomonas palustris To Be Published
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6W25
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![BU of 6w25 by Molmil](/molmil-images/mine/6w25) | Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119 | Descriptor: | CALCIUM ION, Melanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4, OLEIC ACID, ... | Authors: | Yu, J, Gimenez, L.E, Hernandez, C.C, Wu, Y, Wein, A.H, Han, G.W, McClary, K, Mittal, S.R, Burdsall, K, Stauch, B, Wu, L, Stevens, S.N, Peisley, A, Williams, S.Y, Chen, V, Millhauser, G.L, Zhao, S, Cone, R.D, Stevens, R.C. | Deposit date: | 2020-03-04 | Release date: | 2020-04-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding. Science, 368, 2020
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6NPD
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![BU of 6npd by Molmil](/molmil-images/mine/6npd) | X-ray crystal structure of TmpA, 2-trimethylaminoethylphosphonate hydroxylase, with Fe, 2OG, and (R)-1-hydroxy-2-trimethylaminoethylphosphonate | Descriptor: | (2R)-2-hydroxy-N,N,N-trimethyl-2-phosphonoethan-1-aminium, FE (II) ION, TmpA, ... | Authors: | Rajakovich, L.J, Mitchell, A.J, Boal, A.K. | Deposit date: | 2019-01-17 | Release date: | 2019-03-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry, 58, 2019
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6NRB
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![BU of 6nrb by Molmil](/molmil-images/mine/6nrb) | hTRiC-hPFD Class2 | Descriptor: | Prefoldin subunit 1, Prefoldin subunit 2, Prefoldin subunit 3, ... | Authors: | Gestaut, D.R, Roh, S.H, Ma, B, Pintilie, G, Joachimiak, L.A, Leitner, A, Walzthoeni, T, Aebersold, R, Chiu, W, Frydman, J. | Deposit date: | 2019-01-23 | Release date: | 2019-06-19 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (8.7 Å) | Cite: | The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell, 177, 2019
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6PUV
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![BU of 6puv by Molmil](/molmil-images/mine/6puv) | Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin | Descriptor: | C-type lectin domain family 10 member A, CALCIUM ION | Authors: | Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G. | Deposit date: | 2019-07-18 | Release date: | 2020-07-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. Biochemistry, 60, 2021
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8FTT
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6NMR
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![BU of 6nmr by Molmil](/molmil-images/mine/6nmr) | Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 119 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 119 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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7OEZ
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![BU of 7oez by Molmil](/molmil-images/mine/7oez) | Leucine Aminopeptidase A mature enzyme in a complex with leucine | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Watson, K.A, Baltulionis, G. | Deposit date: | 2021-05-04 | Release date: | 2021-06-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | The role of propeptide-mediated autoinhibition and intermolecular chaperone in the maturation of cognate catalytic domain in leucine aminopeptidase. J.Struct.Biol., 213, 2021
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6Q8Z
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![BU of 6q8z by Molmil](/molmil-images/mine/6q8z) | Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide | Descriptor: | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, beta-D-galactopyranose, ... | Authors: | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | Deposit date: | 2018-12-16 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of human galactokinase 1 bound with N-(Cyclobutylmethyl)-1,5-dimethyl-1H-pyrazole-4-carboxamide To Be Published
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6XWU
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![BU of 6xwu by Molmil](/molmil-images/mine/6xwu) | Crystal structure of drosophila melanogaster CENP-C cumin domain | Descriptor: | RE68959p | Authors: | Jeyaprakash, A.A, Medina-Pritchard, B, Lazou, V, Zou, J, Byron, O, Abad, M.A, Rappsilber, J, Heun, P. | Deposit date: | 2020-01-24 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1. Embo J., 39, 2020
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6W32
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![BU of 6w32 by Molmil](/molmil-images/mine/6w32) | Crystal structure of Sfh5 | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Phosphatidylinositol transfer protein SFH5 | Authors: | Gulten, G, Khan, D, Aggarwal, A, Krieger, I, Sacchettini, J.C, Bankaitis, V.A. | Deposit date: | 2020-03-08 | Release date: | 2020-11-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. Elife, 9, 2020
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8FKQ
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6NE0
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![BU of 6ne0 by Molmil](/molmil-images/mine/6ne0) | Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14) | Descriptor: | CRISPR RNA (60-MER), CRISPR target DNA (44-MER), CRISPR-associated endonuclease Cas6/Csy4, ... | Authors: | Chowdhury, S, Rollins, M.F, Carter, J, Golden, S.M, Miettinen, H.M, Santiago-Frangos, A, Faith, D, Lawrence, M.C, Wiedenheft, B, Lander, G.C. | Deposit date: | 2018-12-15 | Release date: | 2018-12-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry. Mol. Cell, 74, 2019
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7BEY
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![BU of 7bey by Molmil](/molmil-images/mine/7bey) | Het-N2-SO3- - De novo designed three-helix heterodimer with Cysteine S-sulfate at the N2 position of the alpha-helix | Descriptor: | 'Cys-N2-SO3-' Strand, 'Positive' Strand, SULFATE ION | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. | Deposit date: | 2021-01-06 | Release date: | 2021-03-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
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5MDX
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![BU of 5mdx by Molmil](/molmil-images/mine/5mdx) | Cryo-EM structure of the PSII supercomplex from Arabidopsis thaliana | Descriptor: | CHLOROPHYLL A, CHLOROPHYLL B, Chlorophyll a-b binding protein 1, ... | Authors: | van Bezouwen, L.S, Caffarri, S, Kale, R.S, Kouril, R, Thunnissen, A.M.W.H, Oostergetel, G.T, Boekema, E.J. | Deposit date: | 2016-11-13 | Release date: | 2017-06-21 | Last modified: | 2019-04-24 | Method: | ELECTRON MICROSCOPY (5.3 Å) | Cite: | Subunit and chlorophyll organization of the plant photosystem II supercomplex. Nat Plants, 3, 2017
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7BOT
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![BU of 7bot by Molmil](/molmil-images/mine/7bot) | Human SIRT2 in complex with myristoyl thiourea inhibitor, No.23 | Descriptor: | N-dodecylmethanethioamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | Authors: | Kudo, N, Olsen, C.A, Minoru, Y. | Deposit date: | 2020-03-19 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration. Rsc Chem Biol, 2, 2021
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7BQ6
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![BU of 7bq6 by Molmil](/molmil-images/mine/7bq6) | Crystal structure of Pennisetum glaucum monodehydroascorbate reductase | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Sonkar, K.S, Arulandu, A, Achary, M.M, Reddy, M.K. | Deposit date: | 2020-03-24 | Release date: | 2021-03-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Biochemical and structural characterization of a robust and thermostable ascorbate recycling monodehydroascorbate reductase (MDHAR) from stress adapted pearl millet. Biochem.Biophys.Res.Commun., 662, 2023
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6PSM
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![BU of 6psm by Molmil](/molmil-images/mine/6psm) | Crystal structure of PsS1_19B C77S in complex with kappa-neocarrabiose | Descriptor: | 1,2-ETHANEDIOL, 3,6-anhydro-D-galactose, 4-O-sulfo-beta-D-galactopyranose, ... | Authors: | Hettle, A.G, Boraston, A.B. | Deposit date: | 2019-07-12 | Release date: | 2019-09-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Insights into the kappa / iota-carrageenan metabolism pathway of some marinePseudoalteromonasspecies. Commun Biol, 2, 2019
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