6VSD

Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-((thiophen-2-ylthio)methyl)benzoic acid (fragment 13)

Summary for 6VSD

Entry DOI	10.2210/pdb6vsd/pdb
Descriptor	Dihydrofolate reductase, 3-(thiophen-2-ylsulfanylmethyl)benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords	folate pathway, biosynthetic protein
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	38082.97
Authors	Ribeiro, J.A.,Dias, M.V.B. (deposition date: 2020-02-11, release date: 2020-07-15, Last modification date: 2023-10-11)
Primary citation	Ribeiro, J.A.,Hammer, A.,Libreros-Zuniga, G.A.,Chavez-Pacheco, S.M.,Tyrakis, P.,de Oliveira, G.S.,Kirkman, T.,El Bakali, J.,Rocco, S.A.,Sforca, M.L.,Parise-Filho, R.,Coyne, A.G.,Blundell, T.L.,Abell, C.,Dias, M.V.B. Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6:2192-2201, 2020 Cited by PubMed: 32603583 DOI: 10.1021/acsinfecdis.0c00263 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.693 Å)

Structure validation