8DM2
 
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein (focused refinement of NTD) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | 著者 | Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. | | 登録日 | 2022-07-08 | | 公開日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein.
Cell Rep, 42, 2023
|
|
4EL4
 | | Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S/C165S double mutant | | 分子名称: | 1,2-ETHANEDIOL, Botulinum neurotoxin A light chain, GLYCEROL, ... | | 著者 | Stura, E.A, Vera, L, Ptchelkine, D, Dive, V. | | 登録日 | 2012-04-10 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165.
J.Biol.Chem., 287, 2012
|
|
5U5Q
 | | 12 Subunit RNA Polymerase II at Room Temperature collected using SFX | | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | | 著者 | Bushnell, D.A, Oberthur, D, Mariani, V, Yefanov, O, Tolstikova, A, Barty, A. | | 登録日 | 2016-12-07 | | 公開日 | 2017-03-29 | | 最終更新日 | 2019-11-27 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Double-flow focused liquid injector for efficient serial femtosecond crystallography.
Sci Rep, 7, 2017
|
|
3LQN
 | | Crystal Structure of CBS Domain-containing Protein of Unknown Function from Bacillus anthracis str. Ames Ancestor | | 分子名称: | CBS domain protein, FORMIC ACID, GLYCEROL, ... | | 著者 | Kim, Y, Mulligan, R, Hasseman, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2010-02-09 | | 公開日 | 2010-03-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of CBS Domain-containing Protein of Unknown Function from Bacillus anthracis str. Ames Ancestor
To be Published
|
|
8DM4
 | | Cryo-EM structure of SARS-CoV-2 Omicron BA.2 spike protein in complex with Fab 4A8 (focused refinement of NTD and 4A8) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 4A8 heavy chain, ... | | 著者 | Zhu, X, Saville, J.W, Mannar, D, Berezuk, A.M, Cholak, S, Tuttle, K.S, Vahdatihassani, F, Subramaniam, S. | | 登録日 | 2022-07-08 | | 公開日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | | 主引用文献 | Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein.
Cell Rep, 42, 2023
|
|
8E3Q
 | | CRYO-EM STRUCTURE OF the human MPSF | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, ZINC ION, ... | | 著者 | Gutierrez, P.A, Wei, J, Sun, Y, Tong, L. | | 登録日 | 2022-08-17 | | 公開日 | 2023-01-18 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | | 主引用文献 | Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF.
Rna, 28, 2022
|
|
8AGM
 | | Limonene epoxide low pH soak of epoxide hydrolase from metagenomic source ch65 | | 分子名称: | 1,2-ETHANEDIOL, Alpha/beta epoxide hydrolase, CHLORIDE ION, ... | | 著者 | Isupov, M.N, De Rose, S.A, Mitchell, D, Littlechild, J.A. | | 登録日 | 2022-07-20 | | 公開日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.966 Å) | | 主引用文献 | Complexes of epoxide hydrolase from metagenomic source ch65
To Be Published
|
|
1ADD
 | |
6RH1
 | | Revisiting pH-gated conformational switch. Complex HK853-RR468 D53A pH 7 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Response regulator, SULFATE ION, ... | | 著者 | Mideros-Mora, C, Casino, P, Marina, A. | | 登録日 | 2019-04-18 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases.
Nat Commun, 11, 2020
|
|
6I4R
 | | Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase at 1.44 Angstrom resolution | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, mitochondrial, ... | | 著者 | Szabo, E, Wilk, P, Bui, D, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.439 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
|
|
5MD9
 | | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=17, twist=6 | | 分子名称: | Capsid protein p24 C-terminal domain, Capsid protein p24 N-terminal domain | | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | | 登録日 | 2016-11-10 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Science, 354, 2016
|
|
6I4S
 | | Crystal structure of the disease-causing R447G mutant of the human dihydrolipoamide dehydrogenase | | 分子名称: | Dihydrolipoyl dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Szabo, E, Wilk, P, Hubert, A, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | | 登録日 | 2018-11-10 | | 公開日 | 2019-11-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum.Mol.Genet., 28, 2019
|
|
6ZR8
 | |
6EHN
 | | Structural insight into a promiscuous CE15 esterase from the marine bacterial metagenome | | 分子名称: | Carbohydrate esterase MZ0003, GLYCEROL | | 著者 | Helland, R, De Santi, C, Gani, O, Williamson, A.K. | | 登録日 | 2017-09-13 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural insight into a CE15 esterase from the marine bacterial metagenome.
Sci Rep, 7, 2017
|
|
7R4E
 | | RVX-inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium | | 分子名称: | 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... | | 著者 | Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. | | 登録日 | 2022-02-08 | | 公開日 | 2022-04-27 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (3.00001168 Å) | | 主引用文献 | Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase.
Chemistry, 28, 2022
|
|
8AFK
 | | Structure of iRFP variant C15S/N136R/V256C in complex with phycocyanobilin | | 分子名称: | Near-infrared fluorescent protein, PHYCOCYANOBILIN | | 著者 | Remeeva, A, Kovalev, K, Gushchin, I, Fonin, A, Turoverov, K, Stepanenko, O. | | 登録日 | 2022-07-18 | | 公開日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.015 Å) | | 主引用文献 | Structure of iRFP variant C15S/N136R/V256C in complex with phycocyanobilin
To Be Published
|
|
5XII
 | | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6 | | 分子名称: | 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ... | | 著者 | Jain, V, Manickam, Y, Sharma, A. | | 登録日 | 2017-04-26 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
|
|
3LAI
 | | Structural insights into the molecular mechanism of H-NOX activation | | 分子名称: | IMIDAZOLE, Methyl-accepting chemotaxis protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Olea Jr, C, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | | 登録日 | 2010-01-06 | | 公開日 | 2010-03-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.144 Å) | | 主引用文献 | Structural insights into the molecular mechanism of H-NOX activation.
Protein Sci., 19, 2010
|
|
6ZR9
 | |
5INW
 | | Structure of reaction loop cleaved lamprey angiotensinogen | | 分子名称: | C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION | | 著者 | Wei, H, Zhou, A. | | 登録日 | 2016-03-08 | | 公開日 | 2016-10-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
|
|
6EIG
 | | Crystal structure of N24Q/C128T mutant of Channelrhodopsin 2 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Archaeal-type opsin 2, EICOSANE, ... | | 著者 | Kovalev, K, Borshchevskiy, V, Volkov, O, Polovinkin, V, Marin, E, Balandin, T, Astashkin, R, Bamann, C, Bueldt, G, Willlbold, D, Popov, A, Bamberg, E, Gordeliy, V. | | 登録日 | 2017-09-19 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural insights into ion conduction by channelrhodopsin 2.
Science, 358, 2017
|
|
7R4O
 | | Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one | | 分子名称: | 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 | | 著者 | Mackinnon, S, Bezerra, G.A, Krojer, T, Bradley, A.R, Talon, R, Brandeo-Neto, J, Douangamath, A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Oppermann, U, Brennan, P.E, Yue, W.W. | | 登録日 | 2022-02-08 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure of human hydroxyacid oxidase 1 bound with 5-bromo-N-methyl-1H-indazole-3-carboxamide
To Be Published
|
|
5FHJ
 | |
5MD7
 | | The structure of the mature HIV-1 CA hexameric lattice with curvature parameters: tilt=11, twist=-12 | | 分子名称: | Capsid protein p24 | | 著者 | Mattei, S, Glass, B, Hagen, W.J.H, Kraeusslich, H.-G, Briggs, J.A.G. | | 登録日 | 2016-11-10 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | | 主引用文献 | The structure and flexibility of conical HIV-1 capsids determined within intact virions.
Science, 354, 2016
|
|
6RK6
 | | Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity. | | 分子名称: | MANGANESE (II) ION, Oligoribonuclease | | 著者 | Piotrowski, Y, Berg, K, Klebl, D.P, Leiros, I, Larsen, A.N. | | 登録日 | 2019-04-30 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity.
Febs Open Bio, 9, 2019
|
|
