6ZR9

The crystal structure of the complex of hCAVII with 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide

Summary for 6ZR9

• Entry DOI: 10.2210/pdb6zr9/pdb
• Descriptor: Carbonic anhydrase 7, ZINC ION, 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide, ... (4 entities in total)
• Functional Keywords: carbonic anhydrase vii, protein-inhibitor complex, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 31455.68

Authors

D'Ambrosio, K.,De Simone, G.,Di Fiore, A. (deposition date: 2020-07-11, release date: 2021-06-16, Last modification date: 2024-10-23)

• Primary citation: D'Ambrosio, K.,Di Fiore, A.,Buonanno, M.,Kumari, S.,Tiwari, M.,Supuran, C.T.,Mishra, C.B.,Monti, S.M.,De Simone, G.; The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development; New J.Chem., 45:147-152, 2021; DOI: 10.1039/D0NJ03544K

Experimental method

X-RAY DIFFRACTION (2.05 Å)