6ZR8

The crystal structure of 2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II

Summary for 6ZR8

• Entry DOI: 10.2210/pdb6zr8/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, 2-[4-(diphenylmethyl)piperazin-1-yl]-~{N}-(4-sulfamoylphenyl)ethanamide, ... (4 entities in total)
• Functional Keywords: protein-inhibitor adduct, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30007.30

Authors

Di Fiore, A.,De Simone, G.,D'Ambrosio, K. (deposition date: 2020-07-11, release date: 2021-06-16, Last modification date: 2024-01-31)

• Primary citation: D'Ambrosio, K.,Di Fiore, A.,Buonanno, M.,Kumari, S.,Tiwari, M.,Supuran, C.T.,Mishra, C.B.,Monti, S.M.,De Simone, G.; The crystal structures of 2-(4-benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide in complex with human carbonic anhydrase II and VII provide insights into selective CA inhibitor development; New J.Chem., 45:147-152, 2021; DOI: 10.1039/D0NJ03544K

Experimental method

X-RAY DIFFRACTION (1.79 Å)