4EL4

Crystal structure of the catalytic domain of botulinum neurotoxin BoNT/A C134S/C165S double mutant

Summary for 4EL4

Entry DOI	10.2210/pdb4el4/pdb
Related	2ISE 3BWI 4EJ5 4ELC
Descriptor	Botulinum neurotoxin A light chain, ZINC ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	metalloprotease, peptidase m27 superfamily, clostridial neurotoxin zinc protease, human target snap-25, hydrolase
Biological source	Clostridium botulinum
Cellular location	Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845
Total number of polymer chains	1
Total formula weight	51323.09
Authors	Stura, E.A.,Vera, L.,Ptchelkine, D.,Dive, V. (deposition date: 2012-04-10, release date: 2012-08-15, Last modification date: 2023-09-20)
Primary citation	Stura, E.A.,Le Roux, L.,Guitot, K.,Garcia, S.,Bregant, S.,Beau, F.,Vera, L.,Collet, G.,Ptchelkine, D.,Bakirci, H.,Dive, V. Structural Framework for Covalent Inhibition of Clostridium botulinum Neurotoxin A by Targeting Cys165. J.Biol.Chem., 287:33607-33614, 2012 Cited by PubMed: 22869371 DOI: 10.1074/jbc.M112.396697 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation