5LUU
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![BU of 5luu by Molmil](/molmil-images/mine/5luu) | Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment | 分子名称: | 1,2-ETHANEDIOL, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, Bromodomain-containing protein 4 | 著者 | Filippakopoulos, P, Picaud, S, Knapp, S, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-11 | 公開日 | 2016-10-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7, 2016
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6G8P
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![BU of 6g8p by Molmil](/molmil-images/mine/6g8p) | 14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... | 著者 | Andrei, S.A, Thijssen, V, Brunsveld, L, Ottmann, C, Milroy, L.G. | 登録日 | 2018-04-09 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A study on the effect of synthetic alpha-to-beta3-amino acid mutations on the binding of phosphopeptides to 14-3-3 proteins. Chem.Commun.(Camb.), 55, 2019
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5D2F
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5LWL
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![BU of 5lwl by Molmil](/molmil-images/mine/5lwl) | MaeR D54A mutant response regulator bound to sulfate | 分子名称: | SULFATE ION, Transcriptional regulatory protein | 著者 | Miguel-Romero, L, Casino, P, Landete, J.M, Monedero, V, Zuniga, M, Marina, A. | 登録日 | 2016-09-18 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates. Sci Rep, 7, 2017
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5LVK
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6CFL
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![BU of 6cfl by Molmil](/molmil-images/mine/6cfl) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Tereshchenkov, A.G, Dobosz-Bartoszek, M, Osterman, I.A, Marks, J, Sergeeva, V.A, Kasatsky, P, Komarova, E.S, Stavrianidi, A.N, Rodin, I.A, Konevega, A.L, Sergiev, P.V, Sumbatyan, N.V, Mankin, A.S, Bogdanov, A.A, Polikanov, Y.S. | 登録日 | 2018-02-15 | 公開日 | 2018-03-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J. Mol. Biol., 430, 2018
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5U9F
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![BU of 5u9f by Molmil](/molmil-images/mine/5u9f) | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. | 登録日 | 2016-12-16 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
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6CFK
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![BU of 6cfk by Molmil](/molmil-images/mine/6cfk) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Tereshchenkov, A.G, Dobosz-Bartoszek, M, Osterman, I.A, Marks, J, Sergeeva, V.A, Kasatsky, P, Komarova, E.S, Stavrianidi, A.N, Rodin, I.A, Konevega, A.L, Sergiev, P.V, Sumbatyan, N.V, Mankin, A.S, Bogdanov, A.A, Polikanov, Y.S. | 登録日 | 2018-02-15 | 公開日 | 2018-03-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J. Mol. Biol., 430, 2018
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8U4L
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![BU of 8u4l by Molmil](/molmil-images/mine/8u4l) | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | 著者 | Trenker, R, Diwanji, D, Bingham, T, Verba, K.A, Jura, N. | 登録日 | 2023-09-10 | 公開日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structure of the HER2/HER4/NRG1b Heterodimer Extracellular Domain To Be Published
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6G4Y
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![BU of 6g4y by Molmil](/molmil-images/mine/6g4y) | Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a | 分子名称: | 10-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrolidin-3-yl]ethynyl]-~{N}3-(oxan-4-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase 14, SULFATE ION | 著者 | Hole, A.J, Hymowitz, S.G, McEwan, P.A. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61, 2018
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4Y53
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![BU of 4y53 by Molmil](/molmil-images/mine/4y53) | Endothiapepsin in complex with fragment 54 | 分子名称: | 1,2-ETHANEDIOL, 3-(3,4-difluorophenyl)imidazo[2,1-c][1,2,4]triazine, Endothiapepsin, ... | 著者 | Radeva, N, Heine, A, Klebe, G. | 登録日 | 2015-02-11 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Crystallographic Fragment Screening of an Entire Library To Be Published
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6ZNO
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![BU of 6zno by Molmil](/molmil-images/mine/6zno) | The pointed end complex of dynactin with the p150 projection docked | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... | 著者 | Lau, C.K, Lacey, S.E, Carter, A.P. | 登録日 | 2020-07-06 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end. Embo J., 40, 2021
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5LZ2
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![BU of 5lz2 by Molmil](/molmil-images/mine/5lz2) | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | 分子名称: | 3-cyano-~{N}-cyclopropyl-benzenesulfonamide, CHLORIDE ION, Platelet-activating factor acetylhydrolase, ... | 著者 | Woolford, A, Day, P. | 登録日 | 2016-09-29 | 公開日 | 2016-12-21 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem., 59, 2016
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6GAV
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![BU of 6gav by Molmil](/molmil-images/mine/6gav) | Extremely 'open' clamp structure of DNA gyrase: role of the Corynebacteriales GyrB specific insert | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA gyrase subunit B,DNA gyrase subunit A | 著者 | Petrella, S, Capton, E, Alzari, P.M, Aubry, A, MAyer, C. | 登録日 | 2018-04-12 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity. Structure, 27, 2019
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5LZ7
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![BU of 5lz7 by Molmil](/molmil-images/mine/5lz7) | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | 分子名称: | 2-fluoranyl-5-[2-[(4~{R})-4-methyl-2-oxidanylidene-4-phenyl-pyrrolidin-1-yl]ethoxy]benzenecarbonitrile, CHLORIDE ION, Platelet-activating factor acetylhydrolase | 著者 | Woolford, A, Day, P. | 登録日 | 2016-09-29 | 公開日 | 2016-12-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem., 59, 2016
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5LZI
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![BU of 5lzi by Molmil](/molmil-images/mine/5lzi) | Porcine heat-labile enterotoxin R13H in complex with inhibitor MM146 | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[(2~{R})-3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-2-(2-phenylethanoylamino)propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[(2~{S})-3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-2-(2-phenylethanoylamino)propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... | 著者 | Heggelund, J.E, Mackenzie, A, Krengel, U. | 登録日 | 2016-09-29 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics. Sci Rep, 7, 2017
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6V4T
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![BU of 6v4t by Molmil](/molmil-images/mine/6v4t) | MPER-TMD of HIV-1 Env bound with the entry inhibitor S2C3 | 分子名称: | 4,4'-(decane-1,10-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolin-4-ium), Envelope glycoprotein gp160 | 著者 | Xiao, T, Frey, G, Fu, Q, Lavine, C.L, Scott, D.A, Seaman, M.S, Chou, J.J, Chen, B. | 登録日 | 2019-11-30 | 公開日 | 2020-04-01 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat.Chem.Biol., 16, 2020
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6GDS
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![BU of 6gds by Molmil](/molmil-images/mine/6gds) | Holliday Junctions formed from Telomeric DNA | 分子名称: | Telomeric DNA (5' CTAACCCTAA) 10mer, Telomeric DNA (5'-TTAGGGTTAG)-3') 10mer | 著者 | Parkinson, G.N, Haider, S, Li, P, Khiali, S, Munnur, D, Ramanathan, A. | 登録日 | 2018-04-24 | 公開日 | 2018-11-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Holliday Junctions Formed from Human Telomeric DNA. J. Am. Chem. Soc., 140, 2018
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6G7C
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![BU of 6g7c by Molmil](/molmil-images/mine/6g7c) | Nt2-CTD domains of the TssA component from the type VI secretion system of Aeromonas hydrophila. | 分子名称: | ImpA-related domain protein | 著者 | Dix, S.D, Owen, H.J, Sun, R, Ahmad, A, Shastri, S, Spiewak, H.L, Mosby, D.J, Harris, M.J, Batters, S.L, Tzokov, S.B, Sedelnikova, S.E, Baker, P.J, Bullough, P.A, Rice, D.W, Thomas, M.S. | 登録日 | 2018-04-05 | 公開日 | 2018-11-21 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Structural insights into the function of type VI secretion system TssA subunits. Nat Commun, 9, 2018
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5M2C
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![BU of 5m2c by Molmil](/molmil-images/mine/5m2c) | Structural tuning of CD81LEL (space group P32 1 2) | 分子名称: | CD81 antigen, PHOSPHATE ION | 著者 | Cunha, E.S, Sfriso, P, Rojas, A.L, Roversi, P, Hospital, A, Orozco, M, Abrescia, N.G. | 登録日 | 2016-10-12 | 公開日 | 2016-12-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.961 Å) | 主引用文献 | Mechanism of Structural Tuning of the Hepatitis C Virus Human Cellular Receptor CD81 Large Extracellular Loop. Structure, 25, 2017
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6ZQJ
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![BU of 6zqj by Molmil](/molmil-images/mine/6zqj) | Cryo-EM structure of trimeric prME spike of Spondweni virus | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, prM | 著者 | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | 登録日 | 2020-07-09 | 公開日 | 2021-01-20 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins. Nat Commun, 12, 2021
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7O0M
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![BU of 7o0m by Molmil](/molmil-images/mine/7o0m) | Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023) | 分子名称: | 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... | 著者 | Bedi, R.K, Dolbois, A, Caflisch, A. | 登録日 | 2021-03-26 | 公開日 | 2021-09-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023) To Be Published
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5U9G
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![BU of 5u9g by Molmil](/molmil-images/mine/5u9g) | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. | 登録日 | 2016-12-16 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
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8FWS
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![BU of 8fws by Molmil](/molmil-images/mine/8fws) | Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. | 登録日 | 2023-01-23 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Cell Rep, 42, 2023
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8CX5
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![BU of 8cx5 by Molmil](/molmil-images/mine/8cx5) | Crystal Structure of small molecule alpha,beta-ketoamide 4 covalently bound to K-Ras(G12R) | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Zhang, Z, Morstein, J, Ecker, A, Guiley, K.Z, Shokat, K.M. | 登録日 | 2022-05-19 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J.Am.Chem.Soc., 144, 2022
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