5LUU

Structure of the first bromodomain of BRD4 with a pyrazolo[4,3-c]pyridin fragment

Summary for 5LUU

Entry DOI	10.2210/pdb5luu/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 1-(3-phenyl-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-yl)propan-1-one, ... (4 entities in total)
Functional Keywords	fragment, complex, bromodomain, structural genomics, structural genomics consortium, sgc, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15478.83
Authors	Filippakopoulos, P.,Picaud, S.,Knapp, S.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-11, release date: 2016-10-12, Last modification date: 2017-11-08)
Primary citation	Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L. Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7:1213-1218, 2016 Cited by PubMed: 27994766 DOI: 10.1021/acsmedchemlett.6b00154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation