8EJC
 
 | | Structure of FFAR1-Gq complex bound to TAK-875 | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-16 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8THI
 | | Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (parallel dimer) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, Sialic acid TRAP transporter permease protein SiaT | | 著者 | Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A. | | 登録日 | 2023-07-16 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
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6UKB
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6OQW
 | | E. coli ATP synthase State 3a | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | 著者 | Stewart, A.G, Sobti, M, Walshe, J.L. | | 登録日 | 2019-04-29 | | 公開日 | 2020-06-24 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structures provide insight into how E. coli F1FoATP synthase accommodates symmetry mismatch.
Nat Commun, 11, 2020
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8T8I
 | | Structure of VHH-Fab complex with engineered Elbow FNQIKG, Crystal Kappa and SER substitutions | | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Fab heavy chain, ... | | 著者 | Filippova, E.V, Thompson, I, Kossiakoff, A.A. | | 登録日 | 2023-06-22 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Protein Sci., 33, 2024
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6O4J
 | | Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation | | 分子名称: | Amyloid-beta precursor protein | | 著者 | Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T. | | 登録日 | 2019-02-28 | | 公開日 | 2019-10-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.402 Å) | | 主引用文献 | Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife, 8, 2019
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6O4L
 | | Structure of ALDH7A1 mutant E399D complexed with NAD | | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde dehydrogenase, CHLORIDE ION, ... | | 著者 | Tanner, J.J, Korasick, D.A, Laciak, A.R. | | 登録日 | 2019-02-28 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy.
J. Inherit. Metab. Dis., 43, 2020
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4XDT
 | | Crystal structure of Treponema pallidum TP0796 Flavin trafficking protein, a bifunctional FMN transferase/FAD pyrophosphatase, N55Y mutant, FAD bound form | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, FAD:protein FMN transferase, ... | | 著者 | Tomchick, D.R, Brautigam, C.A, Deka, R.K, Norgard, M.V. | | 登録日 | 2014-12-19 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.452 Å) | | 主引用文献 | Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein.
Mbio, 6, 2015
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6ORM
 | | Crystal Structure of Peruvianin-I (Cysteine peptidase from Thevetia peruviana latex) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peruvianin-I, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Cruz, W.T, Bezerra, E.H.S, da Silva, F.M.S, Freire, V.N, Ramos, M.V, Rocha, B.A.M, Freitas, C.D.T. | | 登録日 | 2019-04-30 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Crystal structure and specific location of a germin-like protein with proteolytic activity from Thevetia peruviana.
Plant Sci., 298, 2020
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8F5T
 | | Rabbit muscle pyruvate kinase in complex with sodium and magnesium | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Holyoak, T, Fenton, A.W. | | 登録日 | 2022-11-15 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes.
Database (Oxford), 2023, 2023
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8TIC
 | | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylic acid, CHLORIDE ION, ... | | 著者 | Sudom, A, Min, X. | | 登録日 | 2023-07-19 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.
J.Med.Chem., 66, 2023
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8THJ
 | | Cryo-EM structure of the Tripartite ATP-independent Periplasmic (TRAP) transporter SiaQM from Haemophilus influenzae (antiparallel dimer) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, PHOSPHATIDYLETHANOLAMINE, SODIUM ION, ... | | 著者 | Davies, J.S, Currie, M.C, Dobson, R.C.J, North, R.A. | | 登録日 | 2023-07-16 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter.
Elife, 12, 2024
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8TJC
 | | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 8a | | 分子名称: | (6M)-1-[(2R)-3,3-dimethylbutan-2-yl]-6-[(5S)-5-methyl-4-oxo-5-phenyl-4,5-dihydro-1H-imidazol-2-yl]-1,3-dihydro-2H-benzimidazol-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Sudom, A, Min, X. | | 登録日 | 2023-07-20 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.
J.Med.Chem., 66, 2023
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8SYJ
 | | Structure of apurinic/apyrimidinic DNA lyase TK0353 from Thermococcus kodakarensis (Iodide crystal form) | | 分子名称: | GLYCEROL, IODIDE ION, SULFATE ION, ... | | 著者 | Eckenroth, B.E, Gardner, A.F, Doublie, S. | | 登録日 | 2023-05-25 | | 公開日 | 2023-12-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold.
J.Biol.Chem., 300, 2023
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8TQO
 | | Eukaryotic translation initiation factor 2B tetramer | | 分子名称: | Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, Translation initiation factor eIF-2B subunit epsilon, ... | | 著者 | Wang, L, Lawrence, R, Sangwan, S, Anand, A, Shoemaker, S, Deal, A, Marqusee, S, Watler, P. | | 登録日 | 2023-08-08 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
Nat.Chem.Biol., 20, 2024
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6RFW
 | | Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1039 | | 分子名称: | 3-[5-[(4~{a}~{R},8~{a}~{S})-4-oxidanylidene-3-propan-2-yl-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-[2-(2-fluorophenyl)ethyl]prop-2-ynamide, FORMIC ACID, GLYCEROL, ... | | 著者 | Singh, A.K, Brown, D.G. | | 登録日 | 2019-04-16 | | 公開日 | 2019-07-24 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.183 Å) | | 主引用文献 | Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Bioorg.Med.Chem., 27, 2019
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8TQZ
 | | Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit | | 分子名称: | Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, ... | | 著者 | Wang, L, Lawrence, R, Sangwan, S, Anand, A, Shoemaker, S, Deal, A, Marqusee, S, Watler, P. | | 登録日 | 2023-08-08 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.
Nat.Chem.Biol., 20, 2024
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5LYQ
 | | Crystal structure of the Retinoic Acid Receptor alpha in complex with a synthetic spiroketal agonist and a fragment of the TIF2 co-activator. | | 分子名称: | (2~{R})-6,6,9,9-tetramethylspiro[3,4,7,8-tetrahydrobenzo[g]chromene-2,2'-3,4-dihydrochromene]-6'-carboxylic acid, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha | | 著者 | Andrei, S.A, Ottmann, C. | | 登録日 | 2016-09-28 | | 公開日 | 2017-04-26 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Designed Spiroketal Protein Modulation.
Angew. Chem. Int. Ed. Engl., 56, 2017
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7PYK
 | | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA (NusA elongation complex in more-swiveled conformation) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zhu, C, Guo, X, Weixlbaumer, A. | | 登録日 | 2021-10-10 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
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7N1Z
 | | NMR structure of native PnIA | | 分子名称: | Alpha-conotoxin PnIA | | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | 登録日 | 2021-05-28 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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8P4Q
 | | Structure of the IMP dehydrogenase related protein GUAB3 from Synechocystis PCC 6803 | | 分子名称: | IMP dehydrogenase subunit, INOSINIC ACID, XANTHOSINE-5'-MONOPHOSPHATE | | 著者 | Hernandez-Gomez, A, Fernandez-Justel, D, Buey, R.M. | | 登録日 | 2023-05-23 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution.
Structure, 31, 2023
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7PY7
 | | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (NusA and NusG elongation complex in more-swiveled conformation) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zhu, C, Guo, X, Weixlbaumer, A. | | 登録日 | 2021-10-09 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
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5LEB
 | | Crystal structure of DARPin-DARPin rigid fusion, variant DDD_D12_06_D12_06_D12 | | 分子名称: | DDD_D12_06_D12_06_D12 | | 著者 | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | | 登録日 | 2016-06-29 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
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5LEJ
 | | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a 30-bp operator PrfA-box motif | | 分子名称: | DNA (30-MER), Listeriolysin regulatory protein | | 著者 | Hall, M, Grundstrom, C, Begum, A, Lindberg, M, Sauer, U.H, Almqvist, F, Johansson, J, Sauer-Eriksson, A.E. | | 登録日 | 2016-06-29 | | 公開日 | 2016-12-07 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for glutathione-mediated activation of the virulence regulatory protein PrfA in Listeria.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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7PY5
 | | CryoEM structure of E.coli RNA polymerase elongation complex bound to NusA and NusG (the consensus NusA-NusG-EC) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zhu, C, Guo, X, Weixlbaumer, A. | | 登録日 | 2021-10-09 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Transcription factors modulate RNA polymerase conformational equilibrium.
Nat Commun, 13, 2022
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