8TQZ

Eukaryotic translation initiation factor 2B with a mutation (L516A) in the delta subunit

Summary for 8TQZ

Entry DOI	10.2210/pdb8tqz/pdb
EMDB information	41566
Descriptor	Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, ... (5 entities in total)
Functional Keywords	protein translation, eif2b, integrated stress response, translation
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	530173.34
Authors	Wang, L.,Lawrence, R.,Sangwan, S.,Anand, A.,Shoemaker, S.,Deal, A.,Marqusee, S.,Watler, P. (deposition date: 2023-08-08, release date: 2023-12-06, Last modification date: 2024-04-10)
Primary citation	Lawrence, R.E.,Shoemaker, S.R.,Deal, A.,Sangwan, S.,Anand, A.A.,Wang, L.,Marqusee, S.,Walter, P. A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. Nat.Chem.Biol., 20:422-431, 2024 Cited by PubMed: 37945896 DOI: 10.1038/s41589-023-01453-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation