8TQO
Eukaryotic translation initiation factor 2B tetramer
Summary for 8TQO
| Entry DOI | 10.2210/pdb8tqo/pdb |
| EMDB information | 41510 |
| Descriptor | Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit gamma, Translation initiation factor eIF-2B subunit beta, ... (4 entities in total) |
| Functional Keywords | protein translation, eif2b, integrated stress response, translation |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 229405.56 |
| Authors | Wang, L.,Lawrence, R.,Sangwan, S.,Anand, A.,Shoemaker, S.,Deal, A.,Marqusee, S.,Watler, P. (deposition date: 2023-08-08, release date: 2023-12-06, Last modification date: 2024-04-10) |
| Primary citation | Lawrence, R.E.,Shoemaker, S.R.,Deal, A.,Sangwan, S.,Anand, A.A.,Wang, L.,Marqusee, S.,Walter, P. A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. Nat.Chem.Biol., 20:422-431, 2024 Cited by PubMed: 37945896DOI: 10.1038/s41589-023-01453-9 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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