8TQO

Eukaryotic translation initiation factor 2B tetramer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Translation initiation factor eIF-2B subunit epsilon	polymer	721	80452.6	1	UniProt (Q13144) Pfam (PF02020) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit epsilon
2	I	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	1	UniProt (Q9NR50) Pfam (PF00483) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit gamma
3	D	Translation initiation factor eIF-2B subunit beta	polymer	368	41008.6	1	UniProt (P49770) Pfam (PF01008) In PDB	Homo sapiens (human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
4	E	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	1	UniProt (Q9UI10) Pfam (PF01008) In PDB	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit delta

Sequence modifications

A: 1 - 721 (UniProt: Q13144)

PDB	External Database	Details
Val 587	Ile 587	conflict

D: 2 - 351 (UniProt: P49770)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	229405.6
All*	Total formula weight	229405.6

*Water molecules are not included.