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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8TQO

Eukaryotic translation initiation factor 2B tetramer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0002183biological_processcytoplasmic translational initiation
A0003743molecular_functiontranslation initiation factor activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005851cellular_componenteukaryotic translation initiation factor 2B complex
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0009408biological_processresponse to heat
A0009749biological_processresponse to glucose
A0014002biological_processastrocyte development
A0014003biological_processoligodendrocyte development
A0021766biological_processhippocampus development
A0031369molecular_functiontranslation initiation factor binding
A0034976biological_processresponse to endoplasmic reticulum stress
A0042552biological_processmyelination
A0043065biological_processpositive regulation of apoptotic process
A0043434biological_processresponse to peptide hormone
A0045727biological_processpositive regulation of translation
A0045948biological_processpositive regulation of translational initiation
A0048708biological_processastrocyte differentiation
A0050852biological_processT cell receptor signaling pathway
D0001541biological_processovarian follicle development
D0002183biological_processcytoplasmic translational initiation
D0003743molecular_functiontranslation initiation factor activity
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005851cellular_componenteukaryotic translation initiation factor 2B complex
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0006446biological_processregulation of translational initiation
D0007417biological_processcentral nervous system development
D0009408biological_processresponse to heat
D0009749biological_processresponse to glucose
D0014003biological_processoligodendrocyte development
D0042552biological_processmyelination
D0043434biological_processresponse to peptide hormone
D0045948biological_processpositive regulation of translational initiation
D0048513biological_processanimal organ development
D0050852biological_processT cell receptor signaling pathway
E0001541biological_processovarian follicle development
E0002183biological_processcytoplasmic translational initiation
E0003743molecular_functiontranslation initiation factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005851cellular_componenteukaryotic translation initiation factor 2B complex
E0006412biological_processtranslation
E0006413biological_processtranslational initiation
E0006417biological_processregulation of translation
E0007417biological_processcentral nervous system development
E0009408biological_processresponse to heat
E0009749biological_processresponse to glucose
E0014003biological_processoligodendrocyte development
E0031369molecular_functiontranslation initiation factor binding
E0042552biological_processmyelination
E0043434biological_processresponse to peptide hormone
E0045948biological_processpositive regulation of translational initiation
E0048513biological_processanimal organ development
E0050852biological_processT cell receptor signaling pathway
I0002183biological_processcytoplasmic translational initiation
I0003743molecular_functiontranslation initiation factor activity
I0005085molecular_functionguanyl-nucleotide exchange factor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0005851cellular_componenteukaryotic translation initiation factor 2B complex
I0006412biological_processtranslation
I0006413biological_processtranslational initiation
I0007417biological_processcentral nervous system development
I0008135molecular_functiontranslation factor activity, RNA binding
I0009058biological_processbiosynthetic process
I0009408biological_processresponse to heat
I0009749biological_processresponse to glucose
I0014003biological_processoligodendrocyte development
I0043434biological_processresponse to peptide hormone
I0045948biological_processpositive regulation of translational initiation
I0050852biological_processT cell receptor signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q64350","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues9
DetailsRegion: {"description":"May bind the chemical integrated stress response (ISR) inhibitor ISRIB","evidences":[{"source":"PubMed","id":"25858979","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2026-01-21

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