5LYQ
Crystal structure of the Retinoic Acid Receptor alpha in complex with a synthetic spiroketal agonist and a fragment of the TIF2 co-activator.
Summary for 5LYQ
Entry DOI | 10.2210/pdb5lyq/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, (2~{R})-6,6,9,9-tetramethylspiro[3,4,7,8-tetrahydrobenzo[g]chromene-2,2'-3,4-dihydrochromene]-6'-carboxylic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, rxr, spiroketal, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P19793 |
Total number of polymer chains | 2 |
Total formula weight | 28842.42 |
Authors | Andrei, S.A.,Ottmann, C. (deposition date: 2016-09-28, release date: 2017-04-26, Last modification date: 2024-01-17) |
Primary citation | Scheepstra, M.,Andrei, S.A.,Unver, M.Y.,Hirsch, A.K.H.,Leysen, S.,Ottmann, C.,Brunsveld, L.,Milroy, L.G. Designed Spiroketal Protein Modulation. Angew. Chem. Int. Ed. Engl., 56:5480-5484, 2017 Cited by PubMed: 28407400DOI: 10.1002/anie.201612504 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.17 Å) |
Structure validation
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